ArticleJournal of the American Heart Association2026
Integration of Conventional and Radiomic Features From Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Imaging for Multimodal Prediction of Symptomatic Carotid Atherosclerotic Plaques.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to evaluate an integrated fluorine-18 fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (PET/MRI) model combining conventional and radiomic features for the noninvasive identification of symptomatic extracranial carotid atherosclerotic plaques.
methodsA total of 200 patients with advanced carotid plaques (78 symptomatic, 122 asymptomatic) underwent hybrid fluorine-18 fluorodeoxyglucose PET/MRI. Six MRI morphological features (intraplaque hemorrhage, lipid-rich necrotic core, ruptured fibrous cap, calcification, surface ulceration, and plaque enhancement) and 3 PET metabolic parameters-metabolic uptake, maximum standardized uptake value, and target-to-background ratio-were evaluated. A total of 1991 radiomics were extracted from each of the MRI and PET images, respectively. For each modality, 3 types of models were developed: conventional, radiomics, and combined (incorporating conventional and radiomic features). Diagnostic performance was evaluated using multivariate logistic regression and a linear support vector classifier.
resultsIn MRI-based analysis, surface ulceration and plaque enhancement emerged as independent predictors of symptomatic plaques. In PET-based analysis, standardized uptake value and metabolic uptake were identified as significant independent predictors. The PET conventional model outperformed the MRI conventional model in discriminative ability (areas under the curve: training, 0.899 versus 0.755; internal test, 0.926 versus 0.822; temporal validation, 0.878 versus 0.702). The integrated PET/MRI combined model achieved the best performance, with areas under the curve of 0.962 (training), 0.967 (internal test), and 0.926 (temporal validation), significantly outperforming PET- and MRI-based combined models (all
conclusionsThe fluorine-18 fluorodeoxyglucose PET/MRI combined model integrating morphological, metabolic, and radiomic features outperformed other models, supporting its potential as a noninvasive, high-precision tool for cerebrovascular risk stratification.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.