Evidence map›Paper›PMID 41805115›Full record

ReviewJournal of cell science2026

Clathrin-mediated endocytosis as an axis for the etiopathogenesis of Parkinson's disease.

Amal Kaci, Susanne Herbst, Claudia Manzoni, Patrick A Lewis

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cell science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amal KaciThe Royal Veterinary College, Royal College Street, Camden Town, NW1 0TU, UK.
Susanne HerbstThe Royal Veterinary College, Royal College Street, Camden Town, NW1 0TU, UK.
Claudia ManzoniUCL School of Pharmacy, Brunswick Square, London, WC1N 1AX, UK.
Patrick A LewisThe Royal Veterinary College, Royal College Street, Camden Town, NW1 0TU, UK.ORCID 0000-0003-4537-0489

Funding

Aligning Science Across Parkinson's ASAP 000478Biotechnology and Biological Sciences Research Council BB/T008709/1-2397254Royal Society IF\R2\222002The Royal Veterinary College
6 · The paper itself

Abstract

Clathrin-mediated endocytosis (CME) is a core process in eukaryotic cells, providing a mechanism to selectively take up cargo from the extracellular space into the cytoplasm. Emerging data from both Mendelian and idiopathic forms of Parkinson's disease and parkinsonism syndromes supports a role for key players in CME in determining the risk of developing these neurodegenerative disorders. This Perspective summarizes the current genetic and functional evidence supporting a role for CME in Parkinson's disease, suggesting routes through which CME dysfunction could contribute to the etiopathogenesis of this disorder, and discussing the therapeutic potential for targeting CME in the context of neurodegeneration linked to Parkinson's disease and parkinsonism.

Indexed as

ClathrinEndocytosisParkinson DiseaseAnimalsHumansClathrinClathrin-mediated endocytosisParkinsonismParkinson's diseaseSynaptic transmission

Identifiers

PMID41805115
PMCPMC13006517

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.