Evidence map›Paper›PMID 41805290›Full record

ArticleArchives of endocrinology and metabolism2026

Extracellular vesicles related to familial hypercholesterolemia.

Júnea P de P Silvino, Cinthia E Jannes, Rodrigo M C Pestana, Lucas P de P Silvino, Iêda de F O Silva, Andréa Teixeira-Carvalho, Karina B Gomes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Júnea P de P SilvinoUniversidade Federal de Minas Gerais Faculdade de Medicina Belo Horizonte MG Brasil Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
Cinthia E JannesUniversidade de São Paulo Laboratório de Genética do Instituto do Coração São Paulo SP Brasil Laboratório de Genética do Instituto do Coração (InCor), Universidade de São Paulo, São Paulo, SP, Brasil.
Rodrigo M C PestanaUniversidade Federal de Minas Gerais Faculdade de Medicina Belo Horizonte MG Brasil Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
Lucas P de P SilvinoUniversidade Federal de Minas Gerais Faculdade de Medicina Belo Horizonte MG Brasil Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
Iêda de F O SilvaUniversidade Federal de Minas Gerais Faculdade de Farmácia Belo Horizonte MG Brasil Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
Andréa Teixeira-CarvalhoCentro de Pesquisas René Rachou Belo Horizonte MG Brasil Centro de Pesquisas René Rachou, Belo Horizonte, MG, Brasil.
Karina B GomesUniversidade Federal de Minas Gerais Faculdade de Medicina Belo Horizonte MG Brasil Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to evaluate extracellular vesicles (EVs) in a group of carriers of familial hypercholesterolemia (FH)-related genetic variants compared to those in family members without FH. SUBJECTS AND

methodsAnnexin V-positive EVs (PS+-EVs), cardiomyocyte-derived EVs (CardioEVs), endothelial cell-derived EVs (EEVs), platelet-derived EVs (PEVs) and tissue factor-expressing EVs (TFEVs) were evaluated to compare individuals with FH and genetic variants (n = 16) and non-FH patients without genetic variants (n = 16).

resultsIncreased numbers of PS+-EVs, CardioEVs, EEVs and TFEVs were observed in the group c arrying genetic variants. Furthermore, patients with FH who did not use statins had higher counts of these same EVs than non-FH patients who did not use statins. These EVs were significantly correlated with low-density lipoprotein cholesterol (LDL-c) levels.

conclusionThe data suggest that EVs are related to FH and that their cellular origins could be related to cardiovascular complications commonly observed in this disease.

Indexed as

Extracellular VesiclesHyperlipoproteinemia Type IIAdultBlood PlateletsCholesterol, LDLEndothelial CellsFemaleGenetic VariationHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedMyocytes, CardiacCholesterol, LDLHydroxymethylglutaryl-CoA Reductase Inhibitorscardiovascular diseaseextracellular vesiclesFamilial hypercholesterolemiagenetic variants

Identifiers

PMID41805290
PMCPMC12977345

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.