Evidence map›Paper›PMID 41805579›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Sleep deprivation exhibits an age-dependent effect on infraslow global brain activity.

Yibing Yang, Weiwei Zhao, Yutong Mao, Tianxin Mao, Yao Deng, Yifan Yang, Hengyi Rao, Xiao Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yibing Yang *Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802.ORCID 0009-0000-7145-717X
Weiwei Zhao *Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.
Yutong MaoDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802.ORCID 0009-0006-8115-6200
Tianxin MaoCenter for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.
Yao DengCenter for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.
Yifan YangDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802.ORCID 0000-0001-5384-5072
Hengyi RaoCenter for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.ORCID 0000-0003-2735-2500
Xiao LiuDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802.ORCID 0000-0002-8459-3135

Funding

Neural mechanisms underlying the antidepressant effects of sleep deprivationR01MH107571 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GEHRMAN, PHILIP RICHARD, RAO, HENGYI · 2016 to 2019
$2.6M
Neural basis for differential vulnerability to sleep deprivationR01HL102119 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI RAO, HENGYI · 2010 to 2014
$2.3M
The role of brain arousal in resting-state functional MRIR01NS113889 · NINDS · PENNSYLVANIA STATE UNIVERSITY, THE · PI LIU, XIAO · 2020 to 2024
$1.8M
Multimodal study of infra-slow propagating brain activityRF1MH123247 · NIMH · PENNSYLVANIA STATE UNIVERSITY, THE · PI LIU, XIAO · 2020 to 2020
$1.2M
HHS | NIH | BRAIN Initiative (The BRAIN Initiative) 1RF1MH123247NHLBI NIH HHS R01 HL102119NIH R01 1R01NS113889NIH R01 R01-HL102119NIMH NIH HHS R01 MH107571NIMH NIH HHS RF1 MH123247NINDS NIH HHS R01 NS113889
6 · The paper itself

Abstract

Infraslow (<0.1 Hz) global brain activity, quantified by the global mean blood-oxygenation-level-dependent (gBOLD) signal in resting-state functional magnetic resonance imaging (fMRI), is elevated during sleep and coupled to cerebrospinal fluid (CSF) dynamics, a key pathway for the brain waste clearance implicated in neurodegenerative disorders such as Alzheimer's disease. However, the effect of sleep deprivation on gBOLD activity and its interaction with aging remain poorly understood. Using a rigorously controlled in-laboratory total sleep deprivation (TSD) protocol, we demonstrate that TSD significantly increases both the gBOLD signal amplitude and its coupling with CSF flow, suggesting a compensatory mechanism that may enhance glymphatic clearance following acute sleep loss. Notably, these TSD-induced enhancements exhibit robust age dependency, with markedly attenuated responses in midlife adults (40 to 50 y). The absence of this compensatory mechanism in midlife may exacerbate age-related impairments in neurotoxic clearance and increase dementia susceptibility, thereby offering mechanistic insights into the nexus between sleep disruption, aging, and neurodegeneration.

Indexed as

AgingBrainSleep DeprivationAdultAnimalsHumansMagnetic Resonance ImagingMaleOxygenOxygencerebrospinal fluidglobal brain activitysleep deprivation

Identifiers

PMID41805579
PMCPMC12993984

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.