ArticleJournal of neurology2026
Development and validation of the dysarthria impact scale: a patient-reported outcome for motor speech disorders.
Article in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Automatic Speech Recognition and Acoustic Analysis for Dysarthria Assessment in Telerehabilitation: User-Centered Design and Usability Study.JMIR formative research · 2026Article
- A digital measure of eye movements during reading sensitively captures oculomotor and speech dysfunction, early changes, and disease progression in ataxias.medRxiv : the preprint server for health sciences · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImpaired speech due to dysarthria significantly impacts quality of life. Patient-reported outcomes (PROs) offer critical insight into the lived experience of communication disability and are central to regulatory frameworks for patient-focused drug development.
objectivesTo develop and validate the Dysarthria Impact Scale (DIS), a brief PRO designed to assess the impact of motor speech disorders on quality of life across neurological conditions.
methodsA multi-site, cross-sectional study was conducted with 244 participants, including individuals with Huntington's disease, Parkinson's disease, hereditary ataxias, and head and neck cancer, and healthy controls. The 22-item DIS was developed using expert input and patient feedback and evaluated alongside reference tools (Voice Handicap Index and SF-36). Item reduction procedures yielded two shorter versions (DIS-17 and DIS-6). Validity, reliability, and sensitivity/specificity analyses were performed, and minimal clinically important differences (MCIDs) were estimated using distribution-based methods.
resultsAll DIS versions showed strong convergent validity with the VHI (r = -0.85) and SF-36 (r = 0.72) and were correlated with blinded perceptual speech ratings. DIS-17 and DIS-6 achieved comparable sensitivity (0.93 and 0.88) and specificity (0.84 and 0.86, respectively). Test-retest reliability was high (r = 0.98), with estimated MCIDs and within-subject variability provided. Group differences were observed, with lower DIS scores in ataxia and Parkinson's disease compared to Huntington's disease.
conclusionsThe DIS is a valid, reliable, and practical PRO for quantifying the impact of dysarthria on quality of life. Longitudinal responsiveness remains to be established.
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Registered trials
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