Evidence map›Paper›PMID 41805969›Full record

Trial reportCardiovascular and interventional radiology2026

Elective Transjugular Intrahepatic Portosystemic Shunt Creation in Cirrhosis Improves Body Composition and Function: Pilot Randomized Trial.

Takeshi Suzuki, Kentaro Yamada, Arianna Anoushiravani, Peter Pham, Aaron J Grossberg, Willscott E Naugler, Khashayar Farsad

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cardiovascular and interventional radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05420753 (Single-center Randomized Controlled Trial to Evaluate Body Composition Changes and Clinical Outcomes After Transjugular Intrahepatic Portosystemic Shunt), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05420753 early_phase1unknown statusnot on this map

Single-center Randomized Controlled Trial to Evaluate Body Composition Changes and Clinical Outcomes After Transjugular Intrahepatic Portosystemic Shunt (TIPS) Creation in Patients With Cirrhosis and Complications of Portal Hypertension Awaiting Liver Transplantation

TypeinterventionalSponsorOregon Health and Science UniversityRan2022 to 2025Enrolled22ConditionsCirrhosis, Liver, SarcopeniaArmsTransjugular Intrahepatic Portosystemic Shunt (TIPS) creation
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Takeshi SuzukiDotter Department of Interventional Radiology, Oregon Health and Science University, 3181 S.W. Sam Jackson Park Road, Portland, OR, 97239, USA.
Kentaro YamadaDotter Department of Interventional Radiology, Oregon Health and Science University, 3181 S.W. Sam Jackson Park Road, Portland, OR, 97239, USA.
Arianna AnoushiravaniDotter Department of Interventional Radiology, Oregon Health and Science University, 3181 S.W. Sam Jackson Park Road, Portland, OR, 97239, USA.
Peter PhamDepartment of Radiation Medicine, Oregon Health and Science University, 3181 S.W. Sam Jackson Park Road, L337, Portland, OR, 97239, USA.
Aaron J GrossbergDepartment of Radiation Medicine, Oregon Health and Science University, 3181 S.W. Sam Jackson Park Road, L337, Portland, OR, 97239, USA.
Willscott E NauglerDivision of Gastroenterology and Hepatology, Department of Medicine, Oregon Health and Science University, 3485 S Bond Ave, OC8D, Portland, OR, USA.
Khashayar FarsadDotter Department of Interventional Radiology, Oregon Health and Science University, 3181 S.W. Sam Jackson Park Road, Portland, OR, 97239, USA. farsad@ohsu.edu.ORCID http://orcid.org/0000-0002-3127-7147

Funding

Metabolic vulnerability due to dysregulated lipid metabolism in PDAC cachexiaR37CA280692 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Aaron Grossberg · 2023 to 2026
$1.5M
NCI NIH HHS R37 CA280692
6 · The paper itself

Abstract

purposeSarcopenia and frailty are major determinants of morbidity and mortality in cirrhosis. Transjugular intrahepatic portosystemic shunt (TIPS) creation for refractory ascites may reverse muscle loss, but prospective evidence is lacking. MATERIALS AND

methodsIn this single-center pilot randomized controlled trial, 26 cirrhotic adults with non-emergent complications of portal hypertension were allocated to standard of care (SOC) or SOC + TIPS creation. Fourteen completed six-month follow-up. Primary outcomes were the CT-derived skeletal (SMI) and psoas (PMI) muscle indices, adiposity, Short Physical Performance Battery, and Liver Frailty Index at baseline and at 6 months. Secondary outcomes included quality of life (QOL), MELD score, adverse events, and survival.

resultsIn the TIPS cohort, SMI and PMI increased significantly (both p < 0.05), along with increases in multiple adiposity indices (p < 0.05). In contrast, no body composition metrics showed significant changes in the SOC cohort. Between cohorts, the TIPS group showed significantly greater improvements in PMI (p < 0.05), subcutaneous adipose tissue index (p < 0.01), and intermuscular fat (p < 0.05). A ≥ 10% SMI rise occurred in 71% (5/7, TIPS) versus 14% (1/7, SOC) of patients. All functional scores improved in the TIPS cohort (p < 0.05), with no significant changes in the SOC cohort and significant between-cohort differences (p < 0.05). There were no differences between cohorts in hepatic encephalopathy, MELD scores, or survival (p > 0.05).

conclusionIn this pilot randomized trial, TIPS creation appeared to improve body composition, physical function, and QOL in cirrhotic patients without increasing adverse events. Larger trials are needed to confirm its effects on sarcopenia and frailty. LEVEL OF EVIDENCE: Level 1, Randomized Controlled Trial. CLINICAL

trial registrationClinicalTrials.gov (NCT05420753).

Indexed as

Body CompositionHypertension, PortalLiver CirrhosisPortasystemic Shunt, Transjugular IntrahepaticSarcopeniaAgedFemaleHumansMaleMiddle AgedPilot ProjectsQuality of LifeTreatment OutcomeCirrhosisFrailtyMuscle gainPhysical functionPortal hypertensionSarcopeniaTransjugular intrahepatic portosystemic shunt

Identifiers

PMID41805969
PMCPMC13171096

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.