Observational studyObesity (Silver Spring, Md.)2026
Real-World Weight Loss Is Associated With a Reduction in Cancer Risk.
Observational study in Obesity (Silver Spring, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveObesity is a major risk factor for multiple cancers, yet the impact of nonsurgical weight loss on cancer risk remains uncertain. Our objective was to evaluate whether real-world nonsurgical weight loss is associated with a reduced risk of developing cancer.
methodsWe conducted a retrospective observational study of 143,630 adults (BMI ≥ 30) from an integrated US health system's electronic health records (2000-2022). Cases with incident cancer were compared to matched controls. Using generalized linear models with a logit link, we assessed whether BMI change over 3-, 5-, and 10-year intervals is associated with the risk of diagnosis for obesity-related and other cancers.
resultsAmong 143,630 patients, 7703 cases and 135,927 controls were identified. Each 1% BMI reduction was linked to lower obesity-related cancer risk at 3 years (OR, 0.990; 95% CI, 0.984-0.996; p < 0.001), 5 years (OR, 0.989; 95% CI, 0.984-0.995; p < 0.001), and 10 years (OR, 0.992; 95% CI, 0.984-1.000; p = 0.057). Similar associations were observed for other cancer types across all intervals (OR < 1; p < 0.001).
conclusionsReal-world weight loss was associated with a decreased risk of obesity-related and other cancers.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.