Evidence map›Paper›PMID 41807127›Full record

ArticleComprehensive Physiology2026

Phenotyping of Fontan-Associated Renal Physiology and Disease.

Gaston van Hassel, Jozine M Ter Maaten, Iris E Beldhuis, Eryn T Liem, Bastiaan Zwart, Stephan J L Bakker, Rolf M F Berger, Joost P van Melle

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Comprehensive Physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Pharmacokinetics in the Fontan circulation: a multi-organ puzzle.European heart journal. Cardiovascular pharmacotherapy · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gaston van HasselUniversity of Groningen, Center for Congenital Heart Diseases, Department of Paediatric Cardiology, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, the Netherlands.
Jozine M Ter MaatenDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Iris E BeldhuisDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Eryn T LiemUniversity of Groningen, Center for Congenital Heart Diseases, Department of Paediatric Cardiology, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, the Netherlands.
Bastiaan ZwartCenter for Congenital Heart Diseases, Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Stephan J L BakkerUniversity of Groningen, Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, Groningen, the Netherlands.
Rolf M F BergerUniversity of Groningen, Center for Congenital Heart Diseases, Department of Paediatric Cardiology, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, the Netherlands.ORCID 0000-0002-4385-5784
Joost P van MelleCenter for Congenital Heart Diseases, Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKidney dysfunction is prevalent but insufficiently understood in Fontan patients. We aimed to investigate Fontan-Associated Renal Disease (FARD) through comprehensive phenotyping using biomarkers of renal function and injury, as well as ultrasound assessment of intrarenal hemodynamics.

methodsWe prospectively collected data on serum creatinine and cystatin C levels, and 24-h urine creatinine clearance and albumin excretion in 25 Fontan patients, comparing them to healthy age- and sex-matched controls. Additionally, we measured intrarenal venous and arterial flow patterns using Doppler ultrasonography.

resultsMedian age was 28 (Q1-Q3: 19-35) years, with 48% female. Compared to controls, Fontan patients had similar creatinine-based eGFR (eGFR

conclusionFARD involves a progressive decline in kidney function and glomerular injury. eGFR

Identifiers

PMID41807127
PMCPMC12975410

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.