ArticleScientific reports2026
Self-propelled platinum based magnetite Janus nanomotors prepared from PCL and PHEMA graft copolymer with physicochemical properties motility and peroxidase-like activity.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The present research focused on the manufacturing and designing of a magnetic self-propelled theranostic Janus nanomotor for targeted cancer cell diagnosis and treatment. Platinum (Pt)-based magnetite Janus nanomotors were synthesized by the Pickering Janus emulsions method and used as carriers for the chemotherapy drug Doxorubicin (DOX). Nanomotors were functionalized with a folic acid (FA) ligand and two biocompatible and biodegradable polymers, polycaprolactone (PCL) and poly (2-hydroxyethyl methacrylate) (PHEMA), termed Ac/FA-PHEMA-g-PCL MNP. The hydrodynamic diameter, zeta potential, morphology, drug loading capacity and in-vitro release at pH 7.4 and 5.8, MR contrast agent potential, motility, and peroxidase-like activity of the synthesized nanomotors were analyzed. The findings showed their size of 105.275 ± 26.48 nm and zeta potential of -45.63 ± 0.80 mV and proved cellular internalization, the ability of motion and H
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