Evidence map›Paper›PMID 41807888›Full record

ArticleInternational urology and nephrology2026

Androgen deprivation therapy and kidney function in patients with prostate cancer: an analysis of the RADICAL-PC cohort.

Geethan Baskaran, Jehonathan H Pinthus, Sarah Karampatos, Kelvin K H Ng, Cristina Cano Garcia, Rajibul Mian, Lonnie Pyne, Scott Brimble, Laurence H Klotz, Vincent Fradet and 18 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in International urology and nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT03127631. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03127631 naactive not recruiting

The Role of Androgen Deprivation Therapy In Cardiovascular Disease - A Longitudinal Prostate Cancer Study (RADICAL PC1) & A Randomized Intervention for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer Patients (RADICAL PC2)

Ran2015Enrolled5,000Registered outcomes14Posted comparisons0ConditionsCardiovascular Disease, Prostate CancerArmsACE inhibitor, Exercise, Nutrition, smoking cessation, Statin (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin)
Open the trial in the graph
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Geethan BaskaranTemerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Geethan.baskaran@phri.ca.
Jehonathan H PinthusDepartment of Surgery, Division of Urology, McMaster University, Hamilton, ON, Canada.
Sarah KarampatosHamilton Health Sciences, Hamilton, ON, Canada.
Kelvin K H NgMcMaster University, Hamilton, ON, Canada.
Cristina Cano GarciaDepartment of Urology, Goethe University Frankfurt, University Hospital, Frankfurt, Germany.
Rajibul MianPopulation Health Research Institute, Hamilton, ON, Canada.
Lonnie PyneDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Scott BrimbleDivision of Nephrology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Laurence H KlotzSunnybrook Health Sciences Centre, Toronto, ON, Canada.
Vincent FradetDépartement de Chirurgie, Faculté de Médecine, Université Laval, Québec, QC, Canada.
Joseph B SelvanayagamDepartment of Cardiology, Division of Medicine, Flinders Medical Centre, Flinders University, Bedford Park, Australia.
Avirup GuhaCardio-Oncology Program, Georgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Celestia S HiganoUniversity of British Columbia, Vancouver, BC, Canada.
Álvaro AvezumInternational Research Center, Hospital Alemão Oswaldo Cruz, São Paulo, SP, Brazil.
Ludhmila A HajjarCardio-Oncology Department, Instituto Do Coracao, University of São Paulo, São Paulo, Brazil.
Germano Dallegrave CavalliDivision of Cardiology, Department of Internal Medicine, University of Western Ontario, London, ON, Canada.
Felipe H ValleDivision of Cardiology, Hospital das Clínicas de Porto Alegre, Porto Alegre, Brazil.
Emmanuelle DuceppeDepartment of Medicine, Centre Hospitalier de L'Universite de Montreal, Montreal, QC, Canada.
Cesar D O L DusilekRocio Hospital Research Center, Campo Largo, Paraná, Brazil.
Bobby ShayeganDepartment of Surgery, Division of Urology, McMaster University, Hamilton, ON, Canada.
Rafaela Kirchner PiccoliDivision of Oncology, Department of Internal Medicine, Hospital de Clínicas de Ijuí, Ijuí, Brazil.
Juan Gomez-MesaServicio de Cardiología, Fundación Valle del Lili, Cali, Colombia.
Tamim NiaziDepartment of Oncology, Jewish General Hospital, McGill University, Montreal, QC, Canada.
Margot K DavisUniversity of British Columbia, Vancouver, BC, Canada.
Jose E Cita PardoPontificia Universidad Javeriana, Bogotá, Colombia.
Patrick P LukeUniversity of Western Ontario, London, ON, Canada.
Darryl LeongPopulation Health Research Institute, Hamilton, ON, Canada.
RADICAL PC Investigators

Funding

Prostate Cancer Canada CT2015-01
6 · The paper itself

Abstract

purposeTo evaluate the effect of androgen deprivation therapy (ADT) on kidney function in patients with prostate cancer (PC).

methodsWe analyzed the RADICAL-PC cohort (NCT03127631), a prospective study of patients with PC in 10 countries. Patients were categorized as ADT-exposed or ADT-naïve at baseline. We quantified kidney function using estimated glomerular filtration rate (eGFR), calculated from creatinine measurements obtained at annual visits over a 2 year follow-up period. We used a linear mixed-effects regression model to analyze the association between ADT and eGFR, adjusting for covariates known to affect renal function. We assessed the association between ADT and kidney injury during hospitalization using Cox proportional-hazards regression.

resultsThis analysis included 4 742 patients. The rate of eGFR decline over the 2 year follow-up period was greater in ADT-naïve patients (-1.322 [95% CI, -1.649 to -0.995] ml/min/1.73m

conclusionThis analysis suggests that eGFR declines more modestly in patients initiating ADT than ADT-naïve patients. These findings do not preclude true kidney function decline due to ADT-mediated reduction in creatinine generation, and warrant further investigation.

Indexed as

Androgen deprivation therapyGlomerular filtration rateKidney functionProstate cancer

Identifiers

PMID41807888

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.