ReviewCellular & molecular biology letters2026
The miR-8/miR-200 family: from functional diversification to translational applications.
Review in Cellular & molecular biology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
Funding
Abstract
The miR-8/miR-200 family is a phylogenetically ancient microRNA regulator conserved across bilaterian animals, originating as a single miR-8 isoform in invertebrates and expanding to miR-200a/b/c, miR-141, and miR-429 in vertebrates through gene duplication. This review summarizes the biogenesis, genealogical details, and regulatory roles of the miR-8/miR-200 family. Furthermore, it presents the first comprehensive analysis of its evolutionary trajectory from invertebrates to vertebrates, thereby establishing a foundational understanding that underscores its significant potential for translational applications. Phylogenetic analyses confirm its sequence conservation and lineage-specific distribution, indicating that miR-8 originated in Platyhelminthes, with subsequent isoforms emerging in chordates. Functionally, this family plays pleiotropic roles: in invertebrates, miR-8 regulates immune defense, reproduction, and biosynthesis; in vertebrates, miR-200 subtypes modulate stress responses, epithelial-mesenchymal transition (EMT), tumor suppression, and neurodevelopment via conserved pathways (e.g., Wnt, Notch, PI3K). Cross-species conservation underlies core functions in cell differentiation, apoptosis, and growth, while vertebrate-specific adaptations drive roles in cancer (e.g., targeting ZEB1 in metastasis) and metabolic diseases (e.g., diabetes via β-cell apoptosis). This work explores the translational potential of this family, including nucleic acid pesticides in agriculture (targeting insect miR-8) and diagnostic/therapeutic tools in medicine (miR-200 as cancer biomarkers). Key challenges remain in delivery specificity and addressing functional pleiotropy. Future research should elucidate regulatory networks in non-model species and refine targeted delivery systems for clinical and agricultural applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.