ArticleMicrobial biotechnology2026
Vaginal-Derived Potential Probiotics and Their Postbiotics Alleviate Aerobic Vaginitis via Suppressing TLR4/MyD88/NF-κB Signalling Pathway and Potentially Enhancing Vaginal Barrier.
Article in Microbial biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Antibiotic therapy is currently challenged by drug resistance and high recurrence in aerobic vaginitis (AV), making it urgent to seek novel strategies. In this study, we selected two potential probiotic strains Lactobacillus crispatus YBR-01 (L. crispatus YBR-01) and Lactiplantibacillus plantarum YBR-01 (L. plantarum YBR-01) from our proprietary bacterial library, and comprehensively evaluated the protective potential against AV in mouse model induced by a pathogen cocktail. Supplementation with L. crispatus YBR-01 and L. plantarum YBR-01, either individually or in combination, attenuated vaginal edema, reduced proinflammatory mediators, and restored anti-inflammatory cytokines, with the combination therapy yielding the best results. Mechanistically, the combination of strains significantly inhibited the TLR4/MyD88/NF-κB cascade (p < 0.05), restored vaginal mucosal integrity (p < 0.01), and rebalanced the Th17/Treg immunity (p < 0.05). Moreover, given that postbiotics represent a safe and highly stable alternative strategy with emerging translational potential, the research investigated their impact derived from L. crispatus YBR-01 and L. plantarum YBR-01 on the phenotypic characteristics and molecular profile of the AV mouse model. While postbiotics could synergistically alleviate the AV-like murine phenotype and improve inflammatory markers, the impacts were quantitatively similar as those observed with the live strain combination (p < 0.05). More importantly, the postbiotics effectively mirrored the mechanisms of their live counterparts by downregulating the TLR4/MyD88/NF-κB pathway (p < 0.01), demonstrating the potential to enhance vaginal barrier (p < 0.01) and restoring Th17/Treg balance (p < 0.05), with the combination of postbiotics exhibiting superior advantages over monotherapy. Our study unveiled the therapeutic benefits of both potential probiotic Lactobacillus spp. and their postbiotics in AV, presenting an ideal prospect for clinical translation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.