ArticleBMC oral health2026
Synergistic proanthocyanidin-copper oxygen-generating microneedle enhances anti-inflammatory activity in dental pulp stem cells and macrophage efferocytosis.
Article in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Decoding signaling crosstalk in pulpitis: pathogenesis and precision therapeutics.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundDental pulp inflammation and impaired tissue repair remain critical challenges in endodontic therapy, often exacerbated by hypoxia and dysregulated immune responses.
methodsWe developed a procyanidin-copper-loaded oxygen-generating microneedle hydrogel (CA-PCC-CAT) releasing active components into deeply infected pulp tissue in a pH-responsive manner to exert potent antioxidative and anti-inflammatory effects.
resultsIn vitro experiments demonstrated that the hydrogel effectively protected hDPSCs through its multifunctions, including antibacterial activity, antioxidative stress modulation, anti-inflammatory action, and hypoxia alleviation. Simultaneously, it augmented macrophage efferocytosis by scavenging reactive oxygen species (ROS), thereby facilitating the clearance of apoptotic cells and enhancing tissue repair.
conclusionsThis study represents a promising strategy for developing multifunctional biomaterials to amplify the anti-inflammatory capacity of hDPSCs and advance the field of pulp preservation and regenerative therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.