ArticleRenal failure2026
Transcriptome and weighted gene co-expression network analysis identify hub genes and pathways in rat kidneys after deep hypothermic circulatory arrest.
Article in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAcute kidney injury (AKI) is a frequent and severe complication following aortic dissection repair surgery that utilizes deep hypothermic circulatory arrest (DHCA). This study aimed to identify key hub genes and elucidate the molecular pathways involved in DHCA-associated AKI (DHCA-AKI).
methodsA rat model of DHCA was established, and kidney tissues were harvested for high-throughput transcriptome sequencing. Differentially expressed genes (DEGs) between DHCA and control groups were identified using three independent analytical methods (DESeq2, limma, edgeR). Hub genes were subsequently screened by integrating weighted gene co-expression network analysis (WGCNA) and protein-protein interaction (PPI) network analysis. The iRegulon plugin was used to predict upstream regulators. Kidney function markers and the expression levels of identified hub genes were experimentally validated.
resultsWe identified 154 significant DEGs (80 up- and 74 down-regulated) and 209 key module genes
conclusionDHCA markedly alters the transcriptional landscape in rat kidney tissues. Hub genes and pathways related to inflammation and apoptosis may constitute central pathogenic mechanisms and represent promising therapeutic targets for DHCA-AKI.
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