ArticleRenal failure2026
Lactate induces renal lipid accumulation and aggravates renal fibrosis by inhibiting the PPARα signaling pathway and fatty acid oxidation.
Article in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Chronic kidney disease (CKD) is characterized by renal fibrosis as its core pathological feature, and lipid metabolism disorders are a key driver of disease progression. However, the specific pathological significance of elevated lactate levels in patients with CKD remains unclear. This study aimed to verify the hypothesis that lactate exacerbates renal fibrosis by inhibiting the PPARα/FAO pathway. A total of 15 healthy controls and 75 CKD patients were enrolled. Serum lactate levels were measured, and their correlations with Scr, BUN, eGFR, and lipid metabolism parameters (triglycerides [TG], total cholesterol [TCH]) were analyzed. Meanwhile, unilateral ureteral obstruction (UUO) mouse models and transforming growth factor-β1 (TGF-β1)-induced human proximal tubular epithelial cells (HK-2 cells) were used to validate the regulatory role of lactate in renal fibrosis. Results showed that serum lactate levels in CKD patients significantly increased with disease stage progression, and were positively correlated with Scr, BUN, TG, and TCH (
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