Evidence map›Paper›PMID 41808442›Full record

Trial reportActa physiologica (Oxford, England)2026

Pravastatin Corrects Endothelial Dysfunction in Ex Vivo Uterine Radial Arteries in Preeclampsia.

Nathan M Luque, Leo Leader, Sandra M Lowe, Steven D Horrowitz, Marianne Tare, Victoria Hinkley, Vladimir V Matchkov, Maged M Costantine, Irit Markus, Lu Liu and 2 more

Registry-linked trialAbstract readClinical Trial, Phase IMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Acta physiologica (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01717586 (Pravastatin for the Prevention of Preeclampsia in High-Risk Women), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01717586 phase1completednot on this map

Pravastatin for the Prevention of Preeclampsia in High-Risk Women: A Phase I Pilot Study

TypeinterventionalSponsorThe University of Texas Medical Branch, GalvestonRan2012 to 2024Enrolled48ConditionsPreeclampsiaArmsPravastatin, Placebo
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nathan M LuquePhysiology, School of Biomedical Sciences, University of New South Wales, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0003-3392-566X
Leo LeaderWomen's Health and Royal Hospital for Women, University of New South Wales, Sydney, New South Wales, Australia.ORCID https://orcid.org/0009-0004-6644-690X
Sandra M LoweWomen's Health and Royal Hospital for Women, University of New South Wales, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0003-3858-6011
Steven D HorrowitzWomen's Health and Royal Hospital for Women, University of New South Wales, Sydney, New South Wales, Australia.
Marianne TarePhysiology, and Monash Rural Health, Monash University, Warragul, Victoria, Australia.ORCID https://orcid.org/0000-0003-4574-9368
Victoria HinkleyBiomedical Science, University of the Sunshine Coast, Sippy Downs, Queensland, Australia.ORCID https://orcid.org/0000-0003-3117-2676
Vladimir V MatchkovDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-3303-1095
Maged M CostantineMaternal Fetal Medicine, Department of Obstetrics & Gynecology, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0003-4076-469X
Irit MarkusPharmacology, University of New South Wales, Sydney, New South Wales, Australia.ORCID https://orcid.org/0009-0009-4929-5106
Lu LiuPharmacology, University of New South Wales, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0001-8338-1168
Shaun L SandowBiomedical Science, University of the Sunshine Coast, Sippy Downs, Queensland, Australia.ORCID https://orcid.org/0000-0002-0753-2742
Timothy V MurphyPhysiology, School of Biomedical Sciences, University of New South Wales, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-0110-9548

Funding

University of the Sunshine Coast, SPARK fund
6 · The paper itself

Abstract

aimEndothelium-dependent relaxation in isolated uterine radial arteries from normotensive (NT) and preeclamptic (PE) pregnancies, and the acute effects of pravastatin in the latter vessels were assessed. Pravastatin is hypothesized to alleviate endothelial dysfunction in PE via modulating aspects of NO and endothelium-derived hyperpolarization-mediated relaxation.

methodsRadial arteries isolated from the uterus of NT and PE pregnant patients were incubated with pravastatin (2 mM/6 h), methyl-β-cyclodextrin (10 mM/1 h) in vitro, or vehicle. Vessel function was determined with pressure myography, while related morphology and protein/mRNA expression were characterized using immunohistochemistry, electron microscopy, and qPCR.

resultsEndothelium-dependent, bradykinin-induced NO-mediated relaxation was impaired in radial arteries from PE compared to NT pregnancy, with a reduced intermediate- and large-conductance Ca

conclusionsPravastatin restored endothelium-dependent relaxation in uterine radial arteries from PE pregnancies. Data support the therapeutic potential for pravastatin in treating PE, with ongoing trials determining the validity of its use in the clinical setting.

trial registrationClinicalTrials.gov identifier: NCT01717586.

Indexed as

Endothelium, VascularHydroxymethylglutaryl-CoA Reductase InhibitorsPravastatinPre-EclampsiaRadial ArteryUterine ArteryAdultFemaleHumansPregnancyVasodilationHydroxymethylglutaryl-CoA Reductase InhibitorsPravastatincalcium‐activated potassium channelscaveolaeendothelium‐dependent dilationgap junctionnitric oxide

Identifiers

PMID41808442
PMCPMC12976587

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.