Evidence map›Paper›PMID 41808827›Full record

ArticleFrontiers in immunology2026

Age-associated chemokine receptor expression profiles in human peripheral blood monocyte subsets predict cardiovascular disease risk.

Ravi K Komaravolu, Nandini Chatterjee, Sunil Kumar, Jessica L Allen, Christopher Durant, Runpei Wu, Gabriel Valentin-Guillama, Chantel McSkimming, Fabrizio Drago, Angela M Taylor and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ravi K KomaravoluImmunology Center of Georgia, Augusta University, Augusta, GA, United States.
Nandini ChatterjeeLa Jolla Institute for Immunology, La Jolla, CA, United States.
Sunil KumarImmunology Center of Georgia, Augusta University, Augusta, GA, United States.
Jessica L AllenBeirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, United States.
Christopher DurantImmunology Center of Georgia, Augusta University, Augusta, GA, United States.
Runpei WuImmunology Center of Georgia, Augusta University, Augusta, GA, United States.
Gabriel Valentin-GuillamaImmunology Center of Georgia, Augusta University, Augusta, GA, United States.
Chantel McSkimmingBeirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, United States.
Fabrizio DragoBeirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, United States.
Angela M TaylorBeirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, United States.
Yury I MillerDivision of Endocrinology, University of California San Diego, San Diego, La Jolla, CA, United States.
Klaus LeyImmunology Center of Georgia, Augusta University, Augusta, GA, United States.
Coleen A McNamaraBeirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, United States.
Ahmad AlimadadiImmunology Center of Georgia, Augusta University, Augusta, GA, United States.
Catherine C HedrickImmunology Center of Georgia, Augusta University, Augusta, GA, United States.

Funding

Vascular macrophages and T cells in atherosclerosisR35HL145241 · AUGUSTA UNIVERSITY · 2025 to 2025
$770k
NHLBI NIH HHS R35 HL145241
6 · The paper itself

Abstract

Background: Aging is a major contributor to chronic inflammation and coronary artery disease (CAD), yet how age influences monocyte chemokine receptor expression in relation to disease severity remains incompletely defined. Methods and results: We performed high-dimensional single-cell antibody sequencing (Ab-Seq) of peripheral blood mononuclear cells from 61 participants (ages 42-78 years) enrolled in the Coronary Assessment of Virginia (CAVA) cohort. Aging was associated with remodeling of monocyte populations, including a reduction in anti-inflammatory classical monocytes and an expansion of immature monocytes. Among younger individuals with severe CAD, intermediate monocyte subcluster iMo_HLA-DR Conclusions: Aging is associated with distinct changes in monocyte chemokine receptor expression that relate to CAD severity. These findings identify age- and disease-associated monocyte immune features that may contribute to CAD progression.

Indexed as

AgingCardiovascular DiseasesMonocytesReceptors, ChemokineAdultAgedAge FactorsBiomarkersFemaleGene Expression ProfilingHumansMaleMiddle AgedBiomarkersReceptors, ChemokineAb-Seqbiomarkerscardiovascular diseasechemokine receptorsGensini scoreimmune aginginflammationmonocytes

Identifiers

PMID41808827
PMCPMC12970611

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.