ReviewFrontiers in immunology2026
T cell-mediated immune responses in xenotransplantation: mechanisms and therapeutic strategies.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Development of a BM7G(TKO/hCD46/hCD55/hTHBD/hEPCR) donor pig with endogenous promoter-driven transgenes for xenotransplantation.Frontiers in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Xenotransplantation has emerged as a promising approach to alleviate the shortage of donor organs. While advances in porcine gene-editing technologies have largely overcome hyperacute rejection, the persistent challenge of T cell- and antibody-mediated rejection reactions continues to impede the long-term survival and clinical translation of xenografts. T cells connect innate and adaptive immunity and are the main effector cells in cell-mediated rejection reactions. The antigen recognition, activation, and effector differentiation of T cells have a crucial impact on the clinical outcomes of xenotransplantation. This review focuses on the immune response process of T cells in xenotransplantation and discusses potential strategies for T cell-mediated rejection reactions. Future exploration of efficient and safe approaches for inducing immune tolerance will be a key direction for prolonging the survival of xenografts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.