Evidence map›Paper›PMID 41809040›Full record

ArticleiScience2026

miR-181d coordinates homologous recombination and anti-tumor immune responses in glioblastoma.

Gatikrushna Singh, Shilpi Singh, Iteeshree Mohapatra, Jay Hou, Andrew Ni, Debashis Barik, Haoyi Zheng, Stefan Kim, Mayur Sharma, Sean Lawler and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Gatikrushna SinghDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA.
Shilpi SinghDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA.
Iteeshree MohapatraBimeda Biologicals, Oakdale, MN 55128, USA.
Jay HouDepartment of Neurosurgery, Warren Alpert School of Medicine, Rhode Island Hospital, Brown University, Providence, RI 02903, USA.
Andrew NiDepartment of Neurosurgery, Warren Alpert School of Medicine, Rhode Island Hospital, Brown University, Providence, RI 02903, USA.
Debashis BarikCenter for Computational Natural Science and Bioinformatics, International Institute of Information Technology, Hyderabad, Telangana 500032, India.
Haoyi ZhengDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA.
Stefan KimDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA.
Mayur SharmaDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA.
Sean LawlerDepartment of Pathology and Laboratory Medicine, Legorreta Cancer Center, Brown University, Providence, RI 02903, USA.
Shobha VasudevanDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02903, USA.
Efrosini KokkoliDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Sasmit SarangiDepartment of Neurology, Warren Alpert School of Medicine, Rhode Island Hospital, Brown University, Providence, RI 02903, USA.
Heinrich ElinzanoDepartment of Neurology, Warren Alpert School of Medicine, Rhode Island Hospital, Brown University, Providence, RI 02903, USA.
Eric T WongDepartment of Neurology, Warren Alpert School of Medicine, Rhode Island Hospital, Brown University, Providence, RI 02903, USA.
Margot Martinez-MorenoDepartment of Neurosurgery, Warren Alpert School of Medicine, Rhode Island Hospital, Brown University, Providence, RI 02903, USA.
Ziya GokaslanDepartment of Neurosurgery, Warren Alpert School of Medicine, Rhode Island Hospital, Brown University, Providence, RI 02903, USA.
Wafik El-DeiryDepartment of Neurosurgery, Warren Alpert School of Medicine, Rhode Island Hospital, Brown University, Providence, RI 02903, USA.
Clark C ChenDepartment of Neurosurgery, Warren Alpert School of Medicine, Rhode Island Hospital, Brown University, Providence, RI 02903, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Master regulatory microRNAs (miRNAs) are characterized by their ability to coordinate distinct yet interconnected pathways to drive transitions in cell states. In this study, we identify miR-181d as a master regulatory miRNA that coordinates acquired resistance and anti-tumoral immunity in glioblastoma, the most prevalent form of adult primary brain cancer. Profiling of miR-181d targets revealed

Indexed as

cancerimmune responsetherapeutics

Identifiers

PMID41809040
PMCPMC12969137

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.