Evidence map›Paper›PMID 41809050›Full record

ArticleiScience2026

Probiotics-enhanced kynurenic acid mitigates cisplatin-induced nephrotoxicity in mice.

Kangxin Li, Hui Yuan, Jieyan Wang, Jiaxin Ou, Guiming Chen, Shiyu Li, Qudi Qiao, Qiannan Deng, Shu-Lan Qin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kangxin LiDepartment of Endocrinology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China.
Hui YuanDepartment of Endocrinology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China.
Jieyan WangDepartment of Urology, People's Hospital of Longhua, Shenzhen, Guangdong 518109, China.
Jiaxin OuCenter for Cancer Immunology, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Guiming ChenHenan International Joint Laboratory of Infection and Immunity, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450001, China.
Shiyu LiDepartment of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Qudi QiaoDepartment of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Qiannan DengInstitute of Biological and Medical Engineering, Guangdong Academy of Sciences, Guangzhou 510075, China.
Shu-Lan QinDepartment of Endocrinology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cisplatin chemotherapy is limited by dose-dependent nephrotoxicity. This study investigates the nephroprotective potential of kynurenic acid (KYNA), a tryptophan metabolite, against cisplatin-induced renal injury. Initial metabolic results revealed significant elevation of serum KYNA levels in cisplatin-treated mice, suggesting endogenous compensatory mechanisms. Systematic pharmacological evaluation demonstrated that intraperitoneal administration (

Indexed as

MicrobiologyMolecular biologyNeuroscience

Identifiers

PMID41809050
PMCPMC12969009

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.