ReviewAesthetic surgery journal. Open forum2026
Collagen Supplementation for Skin and Musculoskeletal Health: An Umbrella Review of Meta-Analyses on Elasticity, Hydration, and Structural Outcomes.
Review in Aesthetic surgery journal. Open forum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The role of protein quality and amino acid composition in preventing sarcopenia and functional decline in older adults.Frontiers in nutrition · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Collagen is a protein with multiple roles within the human body, such as supporting fibroblast formation in the dermis, replacing dead skin cells, protecting organs, giving structure, strength and elasticity to the skin, and a primary role in blood clotting. The aim of the present study was to carry out an umbrella review with integrated meta-analyses to capture the breadth of health outcomes associated with collagen supplementation intake. This umbrella review of systematic reviews includes a search of the use of collagen in PubMed, Embase, Scopus, and Web of Science until March 2025. The effect size for each health outcome was calculated using standardized mean differences, relative risks, or odds ratios, along with their corresponding 95% CIs. Separate meta-analyses were conducted for each outcome and pooled effect sizes were calculated using the inverse variance method under a random-effects model. Meta-regression analyses were conducted to explore potential sources of heterogeneity, and the grading of evidence was carried out using the GRADE. Among 573 papers, 16 systematic reviews for a total of 113 RCTs and 7983 patients were included. In relation to skin, musculoskeletal health, and osteoarthritis conditions, collagen supplementation was consistently associated with favorable outcomes. Regarding oral health and cardiometabolic parameters, the impact of collagen supplementation yielded mixed results. Collagen supplementation demonstrates consistent and clinically meaningful benefits for dermal, bone, and muscular health.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.