ReviewFrontiers in oral health2026
VDR polymorphisms and their influence on oral squamous cell carcinoma susceptibility: a systematic review.
Review in Frontiers in oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Background: Oral Squamous Cell Carcinoma (OSCC) arises through an intricate interplay of underlying genetic traits and surrounding environmental conditions. Variations in the vitamin D receptor (VDR) gene, particularly single-nucleotide polymorphisms (SNPs), may contribute to individual susceptibility and disease progression. Objective: To conduct a systematic review evaluating the role of VDR gene polymorphisms in influencing susceptibility to OSCC. Methods: A systematic literature search was performed in PubMed, Scopus, and Google Scholar to identify human case-control studies evaluating VDR SNPs in relation to OSCC. The methodological quality and potential bias of the selected studies were assessed using the Newcastle-Ottawa Scale (NOS). Due to substantial heterogeneity among the studies in terms of population characteristics, genotyping methods, and outcome measures, a meta-analysis was not performed, and the findings were summarized descriptively. Results: From an initial pool of 90 records, five case-control studies met the inclusion criteria. Qualitative synthesis revealed consistent associations between polymorphisms in the VDR gene, particularly Conclusion: VDR polymorphisms may contribute to OSCC risk by affecting immune and cellular pathways. Although findings are promising, larger, multi-ethnic studies are needed to confirm their clinical significance. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251105619, PROSPERO CRD420251105619.
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