ReviewWorld journal of methodology2026
Update on hypoxic-ischemic brain injury: Prognosis and management.
Review in World journal of methodology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 author.
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Abstract
Hypoxic-ischemic brain injury (HIBI) can occur after cardiac arrest, asphyxiation, carbon monoxide poisoning, and diffuse brain injury. While it is a major cause of mortality and morbidity, there is no consensus on its management. Therefore, I performed a literature review to analyze HIBI pathophysiology, clinical progression, imaging, treatment, and prognosis with a goal to deepen our understanding of best treatment and prognostication options. A search was performed in PubMed, Scopus, Google scholar, EMBASE, and Crossref. The pathophysiology of HIBI consists of the primary insult due to cessation of cerebral oxygen delivery and a secondary hit due to reperfusion injury. The poor clinical prognostic factors are: Absent or extensor motor response, bilaterally absent pupillary light reflex, bilaterally absent corneal reflex, and early status myoclonus. Electroencephalogram can aid in prognostication, while magnetic resonance imaging may reveal restricted diffusion. Treatment guidelines for HIBI have been debated, particularly regarding hyperoxia
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