ArticleWorld journal of methodology2026
White blood cells and neutrophil-to-high density lipoprotein ratio as predictive markers of left ventricular dysfunction in heart failure.
Article in World journal of methodology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSystemic inflammation, especially of white blood cells (WBCs), is being increasingly accepted as a central mechanism underlying the pathogenesis and development of heart failure (HF). Few studies have assessed their effectiveness as accessible and cost-efficient biomarkers for the early detection of left ventricular dysfunction, as well as their potential predictive value in patients with coronary artery disease (CAD).
aimTo explore the correlation between WBC parameters and low left ventricular ejection fraction (LVEF) in HF patients and to evaluate its predictive potential.
methodsTwo-hundred patients with angiographically proven CAD were enrolled in the study. Lymphocyte and neutrophil counts were measured in an automated analyzer. The number of neutrophils was divided by serum level of high density lipoprotein (HDL) to obtain the neutrophil-to-HDL ratio (NHR). Regression analysis was used to examine correlations, and receiver operating characteristic curve analysis was employed to identify predictive value of these hematological markers.
resultsWBC, neutrophils, lymphocytes, and NHR are significantly higher among HF patients with low LVEF. Regression analysis revealed a negative association between LVEF and WBC (
conclusionThese data indicate that parameters of WBCs, notably lymphocytes, neutrophils, and NHR, can act as useful biomarkers for detection of decreased LVEF in patients with HF. These findings suggest that neutrophils, lymphocytes, and NHR are not only routinely available and cost-effective markers but may also serve as early predictors of reduced LVEF in CAD patients, offering potential utility in clinical risk stratification and management. Further research is needed to validate these findings and explore their potential as clinical risk markers and therapeutic targets in CAD with HF.
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