Trial reportFrontiers in neurology
Six-month randomized, double-blind trial of transcranial direct current stimulation in mild Alzheimer's dementia: domain-specific cognitive and neuropsychiatric signals.
Trial report in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Prefrontal transcranial direct current stimulation (tDCS) is a low-risk candidate intervention for cognitive enhancement in Alzheimer's disease (AD), but trial results are heterogeneous and often short-term. We evaluated the 26-week efficacy, safety, and family-level impact of home-based prefrontal tDCS in mild AD. Methods: In this randomized, double-blind, sham-controlled trial, 120 patients with mild AD were allocated to active ( Results: K-MMSE declined slightly in both groups over 26 weeks (active Δ -0.53, sham Δ -0.15), with no significant between-group difference ( Conclusion: In mild AD, 26 weeks of home-based prefrontal tDCS did not improve global cognition vs. sham, although a modest benefit in confrontation naming was observed. The deterioration in caregiver-reported family quality of life highlights the need to weigh potential cognitive gains against family burden in long-term home-based neuromodulation. Clinical trial registration: Clinical Research Information Service (CRIS), KCT0005834.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.