SynthesisFrontiers in microbiology2025
Evaluating the effectiveness of digital health interventions for HIV prevention and treatment adherence among transgender populations: a systematic review and meta-analysis.
Synthesis in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Weissella as an emerging probiotic candidate for IBD: current evidence, challenges, and future perspectives".Antonie van Leeuwenhoek · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Transgender individuals face a disproportionate burden of HIV due to systemic barriers including stigma, discrimination, and limited access to gender-affirming healthcare. Digital health interventions (DHIs), such as mobile applications, telehealth, and online platforms, offer a promising avenue for delivering accessible, tailored, and potentially less stigmatizing HIV prevention and care services to this marginalized population. Objectives: This systematic review and meta-analysis aimed to evaluate the effectiveness of DHIs in improving HIV-related outcomes among transgender individuals. Specifically, it assessed the impact on HIV testing rates, care engagement, and stigma reduction. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a comprehensive search was conducted across five electronic databases-PubMed, Web of Science, Google Scholar, ScienceDirect, and Wiley Online Library-from January 2020 to March 2025. Eligible studies included randomized controlled trials (RCTs), quasi-experimental studies, and observational studies focusing on transgender populations and evaluating DHIs for HIV prevention or care. Screening, data extraction, and quality assessment were performed independently by two reviewers. A random-effects meta-analysis was conducted for quantitative synthesis, with heterogeneity assessed using Results: A total of 11 studies were included in this meta-analysis. The pooled analysis demonstrated a significant positive effect of DHIs on HIV prevention and care outcomes, with an overall effect size (θ) of 1.82 (95% CI: 1.61-2.02). Heterogeneity was low ( Conclusion: Digital health interventions are effective tools for enhancing HIV prevention and care engagement among transgender populations. Their success is likely attributable to increased accessibility, reduced stigma, and tailored design. To maximize impact and equity, future DHIs must be intentionally designed to be culturally competent, gender-affirming, and inclusive of the diverse spectrum of transgender identities, with ongoing research needed to evaluate long-term efficacy and scalability across diverse global settings. Systematic review registration: identifier: CRD420251180979.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.