ArticleWorld journal of gastrointestinal surgery2026
Impact of dexmedetomidine preconditioning on analgesic and postoperative recovery in elderly patients undergoing laparoscopic cholecystectomy.
Article in World journal of gastrointestinal surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundElderly patients undergoing laparoscopic cholecystectomy (LC) are at increased risk for postoperative complications.
aimTo investigate the impact of dexmedetomidine (DEX) preconditioning on postoperative analgesia and recovery in elderly patients undergoing LC.
methodsA retrospective analysis was conducted involving elderly patients (aged ≥ 60 years), who underwent LC between May 2023 and April 2024. Patients were categorized into two groups based on DEX administration protocols: (1) DEX preconditioning anesthesia (DEX-PA) group; and (2) DEX conventional anesthesia group. Postoperative assessments included pain (Visual Analog Scale), sedation (Ramsay Sedation Scale), oxidative stress and inflammation at 6 hours, recovery from anesthesia, gastrointestinal function recovery, cognitive scores (mini-mental state examination), and incidence of adverse events.
resultsAmong 182 patients (DEX-PA = 87, DEX conventional anesthesia = 95), the DEX-PA group showed significantly lower Visual Analog Scale scores (6 hours: 3.86 ± 1.23
conclusionDEX preconditioning prior to anesthesia induction significantly enhances postoperative analgesia, reduces oxidative stress and inflammatory responses, accelerates gastrointestinal and cognitive recovery, and decreases adverse events in elderly patients undergoing LC.
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