Evidence map›Paper›PMID 41809370›Full record

ArticleMolecular therapy. Oncology2026

Retinal organoid screening reveals ABT-737 and luminespib as potential agents against a cone- precursor-derived subtype of retinoblastoma.

Joe Kelk, Agata Rozanska, Eleni Sotiriadou, Dan Astley, Rafiqul Hussain, Adrienne Unsworth, Abbie Gangar, Archie Robinson, Rachel Queen, Jonathan Coxhead and 6 more

Abstract read
In one paragraph

Article in Molecular therapy. Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Joe KelkBiosciences Institute, Newcastle University, Newcastle 1 3BZ, United Kingdom.
Agata RozanskaBiosciences Institute, Newcastle University, Newcastle 1 3BZ, United Kingdom.
Eleni SotiriadouBiosciences Institute, Newcastle University, Newcastle 1 3BZ, United Kingdom.
Dan AstleyClinical and Translational Research Institute, Newcastle University, Newcastle 2 4AE, United Kingdom.
Rafiqul HussainBiosciences Institute, Newcastle University, Newcastle 1 3BZ, United Kingdom.
Adrienne UnsworthBiosciences Institute, Newcastle University, Newcastle 1 3BZ, United Kingdom.
Abbie GangarBiosciences Institute, Newcastle University, Newcastle 1 3BZ, United Kingdom.
Archie RobinsonBiosciences Institute, Newcastle University, Newcastle 1 3BZ, United Kingdom.
Rachel QueenBiosciences Institute, Newcastle University, Newcastle 1 3BZ, United Kingdom.
Jonathan CoxheadBiosciences Institute, Newcastle University, Newcastle 1 3BZ, United Kingdom.
David H SteelBiosciences Institute, Newcastle University, Newcastle 1 3BZ, United Kingdom.
Lyle ArmstrongBiosciences Institute, Newcastle University, Newcastle 1 3BZ, United Kingdom.
Manoj ParulekarBirmingham Women's and Children's NHS Foundation Trust, Birmingham 4 6NH, United Kingdom.
Ian HardcastleNewcastle Cancer Centre at the Northern Institute for Cancer Research Medicinal Chemistry Laboratories, Newcastle 7 7DN, United Kingdom.
Gareth J VealClinical and Translational Research Institute, Newcastle University, Newcastle 2 4AE, United Kingdom.
Majlinda LakoBiosciences Institute, Newcastle University, Newcastle 1 3BZ, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retinoblastoma (Rb) features proliferating cone precursors, particularly those in the G2/M phase, as a major driver population revealed by recent single-cell transcriptomic studies, though other molecular subtypes with distinct cellular origins also contribute to tumor heterogeneity. In the current study, we utilized patient

Indexed as

ABT-737induced pluripotent stem cellsluminespibretinal organoidsretinal pigment epitheliumretinoblastoma

Identifiers

PMID41809370
PMCPMC12969023

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.