Evidence map›Paper›PMID 41809378›Full record

ArticleMaterials today. Bio2026

Biomimetic sequentially gated nanotuners based on amorphous metal-organic frameworks for reprogramming the metabolism-ferroptosis-immunity crosstalk in gliomas.

Bin Wang, Na Yin, Xinrui Liu, Yi Guan, Haiyang Xu, Ying Yu, Yang Bai, Yue Cao, Ziqian Wang, Shiqi Bai and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Bin WangDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, 130021, China.
Na YinState Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Xinrui LiuDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, 130021, China.
Yi GuanDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, 130021, China.
Haiyang XuDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, 130021, China.
Ying YuDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, 130021, China.
Yang BaiDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, 130021, China.
Yue CaoDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, 130021, China.
Ziqian WangDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, 130021, China.
Shiqi BaiGenetic Diagnosis Center, The First Hospital of Jilin University, Changchun, 130021, China.
Shaopeng ZhangDepartment of Colorectal Surgery, Harbin Medical University Cancer Hospital, No.150 Haping Road, Harbin, Heilongjiang, 150081, China.
Donghao QuDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, 130021, China.
Wanying LiState Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Zhijia LvChina-Mongolia Belt and Road Joint Laboratory of Mineral Processing Technology, Inner Mongolia Academy of Science and Technology, Hohhot, 010010, China.
Yunqian LiDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, 130021, China.
Hongquan YuDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, 130021, China.
Yinghui WangState Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioma's metabolic reprogramming fortifies antioxidant defenses and fosters an immunosuppressive microenvironment, thus resulting in robust resistance to ferroptosis-immunotherapy. In this study, a biomimetic sequentially gated amorphous MOF-based nanotuner (ZB@HM) was constructed, which could cascade depletion of metabolic substrates of ferroptosis defense and redistribution of methionine for reprogramming metabolism-ferroptosis-immunity crosstalk. Specifically, we engineered a methionine-inhibitor-loaded amorphous ZIF-82, followed by coating with

Indexed as

FerroptosisGliomasImmunotherapyMetabolic reprogrammingMetal-organic framework

Identifiers

PMID41809378
PMCPMC12969143

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.