Evidence map›Paper›PMID 41809384›Full record

ArticleMaterials today. Bio2026

Hepatocyte growth factor in biosheets promotes autonomous regeneration of cutaneous tissue after transplantation onto a full-thickness skin defect.

Keisuke Suzuki, Hiroko Komura, Ryo Konno, Yusuke Kawashima, Eiichiro Watanabe, Hiroki Sato, Kunio Matsumoto, Ryoko Inaki, Sanshiro Kanazawa, Yukiyo Asawa and 4 more

Abstract read
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In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Keisuke SuzukiDepartment of Pediatric Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Hiroko KomuraDepartment of Tissue Stem Cell and Life Dentistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Ryo KonnoLaboratory of Applied Proteomics Research, Department of Applied Genomics, Kazusa DNA Research Institute, 2-6-7 Kazusa-Kamatari, Kisarazu, Chiba, 290-0818, Japan.
Yusuke KawashimaLaboratory of Applied Proteomics Research, Department of Applied Genomics, Kazusa DNA Research Institute, 2-6-7 Kazusa-Kamatari, Kisarazu, Chiba, 290-0818, Japan.
Eiichiro WatanabeDepartment of Pediatric Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Hiroki SatoDepartment of Science, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama, Kanagawa, 236-0027, Japan.
Kunio MatsumotoNano Life Science Institute, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa, 920-1192, Japan.
Ryoko InakiDepartment of Tissue Stem Cell and Life Dentistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Sanshiro KanazawaDepartment of Oral & Maxillofacial Surgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Yukiyo AsawaDepartment of Tissue Stem Cell and Life Dentistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Atsuhiko HikitaDepartment of Tissue Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Kazuto HoshiDepartment of Tissue Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Jun FujishiroDepartment of Pediatric Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Makoto KomuraDepartment of Tissue Stem Cell and Life Dentistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biosheets and biotubes are collagenous connective tissue membranes that surround unabsorbable molds embedded in living tissues, and can regenerate damaged tissues in various organs following in-situ transplantation. However, the mechanisms underlying tissue regeneration are still unclear. In this study, we analyzed the histological features and cellular composition in the biosheets, and observed dramatic time-dependent changes. We transplanted biosheets into full-thickness wounds in a mouse model, and evaluated skin regeneration through histological analysis in comparison with subcutaneous fascia transplantation. Our findings confirm that biosheets can accelerate epithelialization of skin wounds of mouse more effectively than fascia. To elucidate the mechanism underlying skin regeneration by biosheets, we compared the protein expression in the biosheets and subcutaneous fascia. Proteomics analysis revealed significant differences in the protein profiles of the biosheets and fascia, with marked elevation of hepatocyte growth factor (HGF) in the biosheets. Addition of HGF in situ accelerated angiogenesis and epithelial regeneration in the fascia-transplanted full-thickness wounds in mice. On the other hand, neutralization of HGF impaired the wound healing process following biosheet transplantation. In conclusion, our findings suggest that HGF mediates biosheet-mediated regeneration of cutaneous tissues by contributing to re-epithelialization and angiogenesis.

Indexed as

Hepatocyte growth factorIn-body tissue architectureProteomic analysisSkin regenerationTissue engineeringWound healing

Identifiers

PMID41809384
PMCPMC12969807

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.