ReviewCancer management and research2026
Ferroptosis: A Double-Edged Sword in Cisplatin-Based Cancer Therapy and Acute Kidney Injury.
Review in Cancer management and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ferroptosis, an emerging type of regulated cell death, continues to attract significant focus over recent years, especially within the areas of cancer therapy and acute kidney injury (AKI) research. In therapies that use platinum-based drugs, particularly cisplatin (Cisplatin), ferroptosis exhibits complex, dual role. In a certain context, ferroptosis enhances clinical effects in platinum-based chemotherapy through promoting tumor cell death, while in a different context, it induces excessive damage to kidney cells, potentially leading to onset as well as worsening of AKI. Consequently, gaining a more comprehensive grasp regarding ferroptosis in this context of platinum-based chemotherapy treatment proves essential, as it could improve the efficacy of cancer therapies while also reducing kidney damage. This knowledge forms the theoretical foundation for developing novel treatment strategies, which can enable precision therapies, reduce side effects, as well as eventually enhance well-being in individuals. This narrative review systematically outlines the role and mechanisms of ferroptosis in the anticancer effects of cisplatin and cisplatin-induced acute kidney injury, and discusses targeting ferroptosis as an important strategy for balancing cancer therapy and preventing kidney damage.
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