Evidence map›Paper›PMID 41809434›Full record

ArticleBrain communications2026

Examining neuroimaging biomarkers, plasma biomarkers and cognitive functions in patients with recovered COVID-19 infection: a multicentre study using 7T MRI.

Jr-Jiun Liou, Tales Santini, Jinghang Li, Monica Gireud-Goss, Tiffany F Kautz, Julie Parker-Garza, Juan Carlos Guerrero, Vibhuti Patel, Oluwatobi F Adeyemi, Gabriel A de Erausquin and 21 more

Abstract read
In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors.

Jr-Jiun LiouUniversity of Pittsburgh, Pittsburgh, PA 15260, USA.ORCID https://orcid.org/0000-0002-8800-9557
Tales SantiniUniversity of Pittsburgh, Pittsburgh, PA 15260, USA.ORCID https://orcid.org/0000-0003-4533-9190
Jinghang LiUniversity of Pittsburgh, Pittsburgh, PA 15260, USA.
Monica Gireud-GossUniversity of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Tiffany F KautzUniversity of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Julie Parker-GarzaUniversity of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Juan Carlos GuerreroUniversity of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Vibhuti PatelUniversity of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Oluwatobi F AdeyemiUniversity of Nottingham, Nottingham NG7 2RD, UK.
Gabriel A de ErausquinUniversity of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Valentina R GarbarinoUniversity of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Mohamad HabesUniversity of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.ORCID https://orcid.org/0000-0001-9447-5805
Jayandra J HimaliUniversity of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Christof KarmonikHouston Methodist Research Institute, Houston, TX 77030, USA.
Beth E SnitzUniversity of Pittsburgh, Pittsburgh, PA 15260, USA.
Joseph M MettenburgUniversity of Pittsburgh, Pittsburgh, PA 15260, USA.
Minjie WuUniversity of Pittsburgh, Pittsburgh, PA 15260, USA.
Howard J AizensteinUniversity of Pittsburgh, Pittsburgh, PA 15260, USA.
Anna L MarslandUniversity of Pittsburgh, Pittsburgh, PA 15260, USA.
Peter J GianarosUniversity of Pittsburgh, Pittsburgh, PA 15260, USA.ORCID https://orcid.org/0000-0003-2313-5277
Richard BowtellUniversity of Nottingham, Nottingham NG7 2RD, UK.
Olivier MouginUniversity of Nottingham, Nottingham NG7 2RD, UK.
Penny A GowlandUniversity of Nottingham, Nottingham NG7 2RD, UK.ORCID https://orcid.org/0000-0002-4900-4817
Mohammad Zia KatshuUniversity of Nottingham, Nottingham NG7 2RD, UK.
Farhaan S VahidyHouston Methodist Research Institute, Houston, TX 77030, USA.
Timothy D GirardUniversity of Pittsburgh, Pittsburgh, PA 15260, USA.
Heidi I L JacobsMassachusetts General Hospital, Harvard University, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0001-7620-3822
Akram A HosseiniUniversity of Nottingham, Nottingham NG7 2RD, UK.
Sudha SeshadriUniversity of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Tamer S IbrahimUniversity of Pittsburgh, Pittsburgh, PA 15260, USA.
7T MRI COVID Consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We examined the impact of COVID-19 hospitalization on neuroimaging biomarkers and the association of these neuroimaging biomarkers with cognitive measures and plasma biomarkers. A total of 179 dementia-free people, including 52 hospitalized COVID-19 patients, across four medical centres in the USA and UK underwent 7T brain MRI scans, cognitive tests and blood collection. We found that hospitalized patients exhibited a comparable white matter hyperintensity burden, lower total hippocampal volume and lower plasma glial fibrillary acidic protein concentration, along with poorer memory performance, compared to age-matched non-hospitalized participants. Higher white matter hyperintensity burden was associated with older age, worse cognitive scores and higher plasma biomarker levels; higher total hippocampal volume was associated with younger age, better cognitive scores and lower plasma phosphorylated tau levels. However, these correlation coefficients did not differ between the hospitalized and non-hospitalized groups. Longitudinal studies are needed to clarify the long-term impact of COVID-19-related hospitalization.

Indexed as

glial fibrillary acidic proteinhippocampal subfieldhospitalizationmemorywhite matter hyperintensity

Identifiers

PMID41809434
PMCPMC12967851

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.