ArticleFrontiers in aging neuroscience2026
Gray-white matter covarying impairment in the anterior cingulate cortex revealed by multimodal meta-analysis of post-stroke cognitive impairment.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Post-stroke cognitive impairment (PSCI) involves complex interactions between gray matter (GM) and white matter (WM) pathology, yet their covarying patterns remain poorly characterized. Methods: We conducted a multimodal meta-analysis following PRISMA guidelines (PROSPERO registration number: CRD420251078162). Systematic literature searches identified 7 gray matter volume (GMV) (292 PSCI patients/231 controls) and 8 diffusion tensor imaging fractional anisotropy (DTI-FA) studies (339 PSCI patients/258 controls). Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) was used for voxel-wise meta-analyses. Spatial integration identified GM-WM covarying pathology. Results: PSCI patients showed significant global GMV reduction versus controls ( Conclusion: This study applied SDM-PSI multimodal meta-analysis to delineate characteristic neurostructural damage patterns in PSCI. Key findings encompass gray matter atrophy within frontotemporal cognitive hubs (FWE-corrected). Additionally, exploratory analyses suggested potential covarying GM-WM pathology in the left anterior cingulate/paracingulate gyri (BA 11/25;
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