Evidence map›Paper›PMID 41809636›Full record

ArticleNon-coding RNA research2026

Diagnostic potential of circular RNAs in carotid atherosclerotic plaque vulnerability.

Simona Greco, Federica Perego, Santiago Nicolas Piella, Federico Favretto, Spyros Tastsoglou, Valentina Milani, Sara Boveri, Laura Valentina Renna, Rosanna Cardani, Federico Ambrogi and 4 more

Abstract read
In one paragraph

Article in Non-coding RNA research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Simona GrecoMolecular Cardiology Laboratory, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Federica PeregoDipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Universitá degli Studi di Milano, Milan, Italy.
Santiago Nicolas PiellaMolecular Cardiology Laboratory, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Federico FavrettoMolecular Cardiology Laboratory, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Spyros TastsoglouMolecular Cardiology Laboratory, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Valentina MilaniLaboratory of Biostatistics and Data Management, Scientific Directorate, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Sara BoveriLaboratory of Biostatistics and Data Management, Scientific Directorate, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Laura Valentina RennaBioCor Biobank, IRCCS Policlinico San Donato, San Donato Milanese, Italy.
Rosanna CardaniBioCor Biobank, IRCCS Policlinico San Donato, San Donato Milanese, Italy.
Federico AmbrogiLaboratory of Biostatistics and Data Management, Scientific Directorate, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Giovanni NanoOperative Unit of Vascular Surgery, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Nicoletta BasilicoDipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Universitá degli Studi di Milano, Milan, Italy.
Daniela MazzaccaroOperative Unit of Vascular Surgery, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Fabio MartelliMolecular Cardiology Laboratory, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Vulnerable carotid atherosclerotic plaques are prone to cap rupture and thrombosis, yet definitive assessment still relies on postoperative histology. We investigated whether circulating circular RNAs (circRNAs) in peripheral blood mononuclear cells (PBMCs) can identify plaque vulnerability preoperatively. Method: In patients undergoing carotid endarterectomy, plaques were classified as vulnerable or stable, and PBMC expression of candidate circRNAs ( Results: Conclusions: PBMC circRNAs-particularly

Indexed as

AtherosclerosisCarotid plaqueCircular RNACytokinesNoncoding RNAStroke

Identifiers

PMID41809636
PMCPMC12969012

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.