ArticleAfrican journal of laboratory medicine2026
Friedewald and Martin-Hopkins formulae for estimating low-density lipoprotein cholesterol in a Malagasy population.
Article in African journal of laboratory medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Low-density lipoprotein cholesterol (LDL-C) estimation is commonly used in Madagascar due to cost-effectiveness. However, genetic variability and formula limitations may affect accuracy. Objective: To compare LDL-C estimated by the Friedewald and Martin-Hopkins formulae with directly measured LDL-C in a Malagasy population. Methods: LDL-C values estimated using both formulae were compared with direct LDL-C in 346 samples from patients ≥ 18 years analysed in a biochemistry laboratory. Samples were divided into four groups based on triglyceride levels: < 1.13 mmol/L; 1.13 mmol/L - 1.69 mmol/L; 1.69 mmol/L - 2.26 mmol/L; ≥ 2.26 mmol/L. Results: Both formulae showed a strong, statistically significant correlation with direct LDL-C ( Conclusion: The Friedewald formula showed better correlation, higher concordance and lower mean difference than Martin-Hopkins. Both formulae showed limitations depending on triglyceride concentration. What this study adds: This study evaluates Friedewald and Martin-Hopkins LDL-C estimation against direct measurement in a Malagasy population, highlighting their validity in Africa and implications for clinical decisions in resource-limited settings.
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