Evidence map›Paper›PMID 41809691›Full record

ArticleJournal of pathology informatics2026

The critical role of standards for AI in digital pathology: Digital Pathology Association Concept Paper.

Chhavi Chauhan, Anil Parwani, Vanessa Schumacher, Manu Sebastian, Marilyn M Bui, Pei-Chen Lin, Scott Blakely, Samreen Fathima, Jeff Gibbs, Uwe Horchner and 11 more

Erratum issuedAbstract read
In one paragraph

Article in Journal of pathology informatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Chhavi ChauhanExecutive Director, Open Pathology Education Network, 11063, Cliffside Dr, Fortville, In, 46040-4510.
Anil ParwaniOhio State University, Columbus, OH, USA.
Vanessa SchumacherRoche Pharma Research and Early Development, Roche Innovation Center, Basel, Switzerland.
Manu SebastianDepartment of Veterinary Medicine & Surgery, UT MD Anderson Cancer Center, Houston, TX, USA.
Marilyn M BuiMoffitt Cancer Center, Tampa, FL, USA.
Pei-Chen LinAetherAI, Taipei City, Taiwan.
Scott BlakelyHamamatsu Corporation, Cranberry Township, PA, USA.
Samreen FathimaLoyola University Medical Center, Maywood, IL, USA.
Jeff GibbsHyman, Phelps & McNamara, PC, Washington, DC, USA.
Uwe HorchnerF. Hoffmann-La Roche, CA, USA.
Giovanni LujanOhio State University, Columbus, OH, USA.
Robert Y OsamuraNippon Koukan Hospital.
Liron PantanowitzUniversity of Pittsburgh.
Jennifer SamboyPhilips, NY, USA.
Christina ZiogaCytopathology Department, "G. Papanicolaou" General Hospital of Thessaloniki, Greece.
Markus HerrmannMassachusetts General Hospital and Harvard Medical School, Boston, MA.
Joe YehAether AI, 15F & 15F-1, No. 508, Sec. 7, Zhongxiao E. Rd., Nangang Dist., Taipei, 115011 Taiwan.
Handy OenDepartment of Pathology and Laboratory Medicine, Memorial Sloan-Kettering Cancer Center, New York, USA.
Rajesh C DashDuke University Health System, Durham, NC, USA.
Jochen K LennerzPathology Innovation Collaborative Community (PIcc), 1655 Fort Myer Drive, 12th FloorArlington, Virginia 22209.
Joachim SchmidIlumina, 5200 Illumina Way, San Diego, CA 92122, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Background: The field of pathology has not yet fully realized the potential of artificial intelligence (AI) and digital pathology. Adoption must be driven by demonstrable utility, and successful implementation depends on interoperability and sustainability, which require established standards. We address the imminent challenges facing the field of AI in digital pathology, which currently suffers from a lack of coordinated and adopted standards. Methods: We conducted several roundtable discussions with key opinion leaders from multiple sectors across the healthcare ecosystem. Based on how standards are used, we distinguish different areas of practice (relevance, endorsement, and utility) and emphasize the importance of standards. Results: Our roundtable discussion centered on one key theme: successfully implementing AI in digital pathology depends on achieving a certain level of uniformity across practices. We derive an approach to describe the critical role of standards consisting of seven interdependent areas of practice: value recognition, existing standards, dependencies for AI, failures, management of standards, trends, and a roadmap for accelerated and sustainable adoption. The promise of standards and our approach can be understood as the interconnection of these areas. We address imminent challenges surrounding the field of digital pathology by providing an approach for interoperable, coordinated, and sustainable use of standards across diverse practice settings. Conclusion: With the concepts and frameworks outlined in this article, we highlight the importance of standards in pathology and their crucial role in driving computational advances and enabling AI solutions to enhance patient care.

Indexed as

BiomarkerDICOMFHIRHL7

Identifiers

PMID41809691
PMCPMC12969082

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.