Evidence map›Paper›PMID 41809732›Full record

ArticleInternational journal of genomics2026

Integrative Mendelian Randomization and Pathomics Analysis Using Expression Quantitative Trait Loci and Genome-Wide Association Study Data Identifies Mismatch Repair Genes as Prognostic Biomarkers in Gastric Adenocarcinoma.

Yingqiao Zhang, Dan Li, Yuyao Jin, Wenjuan Zhao, Pengyu Guo, Ziqi Wang, Xinyu Zhu, Zhenqi Ma, Lin Sui, Yanmeng Liang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yingqiao ZhangDepartment of Radiology, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Harbin, 150010, Heilongjiang, China, hrbmu.edu.cn.ORCID https://orcid.org/0009-0007-6282-1567
Dan LiDepartment of Radiology, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Harbin, 150010, Heilongjiang, China, hrbmu.edu.cn.ORCID https://orcid.org/0009-0007-7609-1657
Yuyao JinDepartment of Radiology, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Harbin, 150010, Heilongjiang, China, hrbmu.edu.cn.ORCID https://orcid.org/0009-0000-7877-0214
Wenjuan ZhaoDepartment of Radiology, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Harbin, 150010, Heilongjiang, China, hrbmu.edu.cn.ORCID https://orcid.org/0009-0007-7181-2400
Pengyu GuoDepartment of Radiology, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Harbin, 150010, Heilongjiang, China, hrbmu.edu.cn.ORCID https://orcid.org/0009-0002-6718-6877
Ziqi WangDepartment of Radiology, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Harbin, 150010, Heilongjiang, China, hrbmu.edu.cn.ORCID https://orcid.org/0009-0008-1892-7193
Xinyu ZhuDepartment of Radiology, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Harbin, 150010, Heilongjiang, China, hrbmu.edu.cn.ORCID https://orcid.org/0009-0002-2000-3244
Zhenqi MaDepartment of Radiology, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Harbin, 150010, Heilongjiang, China, hrbmu.edu.cn.ORCID https://orcid.org/0009-0003-7384-3375
Lin SuiDepartment of Radiology, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Harbin, 150010, Heilongjiang, China, hrbmu.edu.cn.ORCID https://orcid.org/0009-0002-2737-8997
Yanmeng LiangDepartment of Radiology, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Harbin, 150010, Heilongjiang, China, hrbmu.edu.cn.ORCID https://orcid.org/0009-0009-2224-0877
Yang LiuDepartment of Radiology, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Harbin, 150010, Heilongjiang, China, hrbmu.edu.cn.ORCID https://orcid.org/0009-0007-0380-6607
Xiushi ZhangDepartment of Radiology, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Harbin, 150010, Heilongjiang, China, hrbmu.edu.cn.ORCID https://orcid.org/0009-0008-5120-1386

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Mismatch repair (MMR) genes are implicated in stomach adenocarcinoma (STAD). This study assessed their causal role in STAD, prognostic value, and developed a histopathology-based model to predict MutS homolog 2 (MSH2) expression. Methods: Using data from the IEU OpenGWAS database, five Mendelian randomization (MR) models evaluated causal links between MMR genes and gastric cancer (GC). Prognostic relevance was assessed via survival analysis. A random forest model using TCGA hematoxylin and eosin-stained images was trained to predict MSH2 expression. Biological insights were explored via pathomics score, gene set enrichment analysis (GSEA), immune infiltration, and tumor mutational burden (TMB). Results: MR analysis identified MLH1 and PMS2 as risk genes, while MSH2 had a protective effect. Cox regression confirmed MSH2 as an independent protective factor (HR = 0.690, 95% CI: 0.487-0.977, Conclusion: MMR genes, especially MSH2, are critical in STAD development and prognosis. The image-based model effectively predicts MSH2 expression, supporting the integration of genomic and histopathologic data for personalized GC care.

Indexed as

gastric adenocarcinomahistopathological image analysisMendelian randomizationmismatch repair genesMutS homolog 2 (MSH2)tumor mutational burden

Identifiers

PMID41809732
PMCPMC12968895

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.