Evidence map›Paper›PMID 41809737›Full record

ReviewInternational journal of cardiology. Cardiovascular risk and prevention2026

Left ventricular systolic recovery after TAVI in severe aortic stenosis: A systematic review and meta-analysis.

Elfatih A Hasabo, Ammar Elgadi, Alaa S Ahmed, Esraa S A Alfadul, Lina Hemmeda, Ruman K Qasba, Walaa Elnaiem, Rakhtan K Qasba, Hesham Elzomor, Ratibah Sawabi and 4 more

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PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of cardiology. Cardiovascular risk and prevention, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Elfatih A HasaboRoyal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences, Dublin, Ireland.
Ammar ElgadiFaculty of Medicine, University of Khartoum, Khartoum, Sudan.
Alaa S AhmedFaculty of Medicine, University of Khartoum, Khartoum, Sudan.
Esraa S A AlfadulFaculty of Medicine, University of Khartoum, Khartoum, Sudan.
Lina HemmedaFaculty of Medicine, University of Khartoum, Khartoum, Sudan.
Ruman K QasbaSher-i-Kashmir Institute of Medical Sciences, Srinagar, India.
Walaa ElnaiemFaculty of Medicine, University of Khartoum, Khartoum, Sudan.
Rakhtan K QasbaGreen Life Medical College and Hospital, Dhaka, Bangladesh.
Hesham ElzomorDepartment of Cardiology, University of Galway, Galway, Ireland.
Ratibah SawabiCardiovascular Research Institute Dublin, and Department of Cardiology, Mater Private Network, Dublin, Ireland.
Omar BaqalDepartment of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZ, USA.
Andreas RückDepartment of Cardiology, Karolinska University Hospital, Stockholm, Sweden.
Nawzad SalehDepartment of Cardiology, Karolinska University Hospital, Stockholm, Sweden.
Osama SolimanRoyal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences, Dublin, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Severe aortic stenosis (AS) imposes chronic pressure overload on the left ventricle (LV), leading to adverse remodeling and systolic dysfunction. While transcatheter aortic valve implantation (TAVI) can reverse this process, the overall prevalence and predictors of LV functional recovery are not fully understood. This study aims to assess the left ventricular ejection fraction (LVEF) recovery following TAVI. Methods: A meta-analysis was conducted in accordance with PRISMA guidelines. The PubMed, Scopus, Web of Science, and Cochrane databases were searched from inception through November 2024 for studies reporting on LVEF improvement after TAVI in patients with severe AS. The primary outcome was LVEF improvement, defined as an absolute increase of ≥10% from baseline. A random-effects model was employed for all pooled analyses to account for inter-study heterogeneity. Results: Eighteen studies encompassing 4782 patients met the inclusion criteria. In the subgroup of patients with reduced LVEF, 14 studies with a total of 3182 patients reported a LV systolic recovery of 49% (95% CI: 40-57; I2 = 97%). The recovery was observed across all follow-up periods, from immediately post-procedure to one-year. A meta-regression has identified that baseline LVEF is a predictor of LV systolic recovery (β = -0.042 (95% CI: [-0.075, -0.008], p = 0.018, I2 = 93.31%). Conclusions: TAVI is associated with substantial LV systolic recovery in nearly half of all patients with pre-existing systolic dysfunction. These findings underscore the prognostic importance of myocardial recovery in this high-risk patient population and can inform clinical decision-making and patient counseling.

Indexed as

Aortic stenosisImprovementLeft ventricular ejection fractionRecoveryTranscatheter aortic valve implantation

Identifiers

PMID41809737
PMCPMC12969045

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.