Evidence map›Paper›PMID 41809760›Full record

ArticleOsteoarthritis and cartilage open2026

Weight loss and physical activity after total knee replacement: Study protocol for the Healthy Living randomized controlled trial.

Christine A Pellegrini, Sara Wilcox, Clare Kennerley, Jungwha Lee, Gabrielle Turner-McGrievy, Elizabeth Regan, Phillip Wessinger, Brian Chen, Harley T Davis, Scott Jamieson and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Christine A PellegriniDepartment of Exercise Science, Arnold School of Public Health, University of South Carolina, 915 Greene Street, Columbia, SC 29208, USA.
Sara WilcoxDepartment of Exercise Science, Arnold School of Public Health, University of South Carolina, 915 Greene Street, Columbia, SC 29208, USA.
Clare KennerleyDepartment of Exercise Science, Arnold School of Public Health, University of South Carolina, 915 Greene Street, Columbia, SC 29208, USA.
Jungwha LeeDepartment of Preventive Medicine, Northwestern University, 680 N. Lake Shore Drive, Chicago, IL 60611, USA.
Gabrielle Turner-McGrievyDepartment of Health Promotion, Education and Behavior, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Elizabeth ReganDepartment of Exercise Science, Arnold School of Public Health, University of South Carolina, 915 Greene Street, Columbia, SC 29208, USA.
Phillip WessingerPrisma Health Orthopedics - Upstate, 200 Patewood Drive, Greenville, SC 29615, USA.
Brian ChenDepartment of Health Services Policy and Management, Arnold School of Public Health, University of South Carolina, 915 Greene Street, Columbia, SC 29208, USA.
Harley T DavisPrisma Health Orthopedics - Midlands, 2 Medical Park Drive, Columbia, SC 29203, USA.
Scott JamiesonDepartment of Exercise Science, Arnold School of Public Health, University of South Carolina, 915 Greene Street, Columbia, SC 29208, USA.
Kailyn HornDepartment of Exercise Science, Arnold School of Public Health, University of South Carolina, 915 Greene Street, Columbia, SC 29208, USA.
Melissa StansburyDepartment of Exercise Science, Arnold School of Public Health, University of South Carolina, 915 Greene Street, Columbia, SC 29208, USA.
J Benjamin JacksonPrisma Health Orthopedics - Midlands, 2 Medical Park Drive, Columbia, SC 29203, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Most people who receive a total knee replacement (TKR) are physically inactive and meet criteria for overweight/obesity, putting them at increased risk of poor functional outcomes and chronic diseases. This paper describes the protocol and procedures for the Healthy Living Study, a 12-month randomized controlled trial comparing outcomes between a patient-centered weight loss program and chronic disease self-management program in adults with TKR. Methods: This study will aim to recruit 212 adults with overweight/obesity (body mass index [BMI] 25-45 kg/m Conclusion: This protocol paper describes the design, rationale, and behavioral interventions for the Healthy Living randomized controlled trial which will target an important clinical population and determine whether a patient-centered weight loss program after TKR is an effective solution to improve outcomes.

Indexed as

Behavioral interventionDietExerciseKnee arthroplastyTechnology

Identifiers

PMID41809760
PMCPMC12969099

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.