ArticleTranslational andrology and urology2026
Efficacy and safety of Compound Chamomile-Lidocaine Gel for postoperative wound management after pediatric circumcision: a multicenter randomized controlled trial.
Article in Translational andrology and urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Circumcision is a common pediatric urological procedure for phimosis, balanitis, or cultural/religious reasons, but postoperative pain, edema, delayed healing, and infection remain key concerns. This study aimed to evaluate the safety and efficacy of Compound Chamomile-Lidocaine Gel for postoperative wound healing in children undergoing classical circumcision. Methods: A multicenter, randomized, controlled trial was conducted in 186 boys aged 8-17 years. Participants were randomly assigned to receive postoperative wound treatment with either saline alone (control group) or saline combined with Compound Chamomile-Lidocaine Gel (intervention group). The primary outcome was the degree of local edema 1 week after surgery, assessed by blinded evaluators. Secondary outcomes included maximum pain score (Visual Analogue Scale, VAS) within 2 days postoperatively, wound healing scores (days 3, 7, 14), total wound healing time, cosmetic scores at 4 weeks, patient satisfaction, and infection rates (days 7, 14). Results: In the per-protocol set (PPS), the incidence of moderate-to-severe edema was significantly lower in the intervention group than in the control group (10.59% Conclusions: Compound Chamomile-Lidocaine Gel combined with saline significantly reduces edema, alleviates pain, and shortens healing time after pediatric circumcision. These findings suggest its potential value in clinical applications. Trial Registration: Chinese Clinical Trial Registry (Registration No. ChiCTR2400084075); Date of Registration: 10/05/2024.
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