Evidence map›Paper›PMID 41809984›Full record

ArticleFrontiers in cellular and infection microbiology2026

Cellular signaling pathway of Shiga toxin-induced ATP release.

Karl Johansson, Ida Arvidsson, Markus Wendler, Ann-Charlotte Kristoffersson, Diana Karpman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Karl JohanssonDepartment of Pediatrics, Clinical Sciences Lund, Lund University, Lund, Sweden.
Ida ArvidssonDepartment of Pediatrics, Clinical Sciences Lund, Lund University, Lund, Sweden.
Markus WendlerDepartment of Pediatrics, Clinical Sciences Lund, Lund University, Lund, Sweden.
Ann-Charlotte KristofferssonDepartment of Pediatrics, Clinical Sciences Lund, Lund University, Lund, Sweden.
Diana KarpmanDepartment of Pediatrics, Clinical Sciences Lund, Lund University, Lund, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Shiga toxin (Stx) is the main virulence factor of enterohemorrhagic Methods: Inhibitors included pertussis toxin, wortmannin, manoalide, 2-aminoethoxydiphenylborate (2-APB), BAPTA-AM and Ca Results: Stx1-mediated ATP release in HeLa cells was blocked by pertussis toxin affecting the Gi/o family of G-protein coupled receptors. ATP release was also abrogated by wortmannin, an inhibitor of phosphoinositide 3-kinase (PI3K), by manoalide, inhibiting phospholipase C, by 2-APB inhibiting IP Conclusion: Stx interaction with HeLa cells initiates a signaling pathway involving membrane G protein, PI3K, phospholipase C and IP

Indexed as

Adenosine TriphosphateShiga ToxinSignal TransductionAnimalsApoptosisFemaleHeLa CellsHumansInositol 1,4,5-Trisphosphate ReceptorsKidneyMiceMice, Inbred BALB CPhosphatidylinositol 3-KinasesTrihexosylceramidesAdenosine TriphosphateglobotriaosylceramideInositol 1,4,5-Trisphosphate ReceptorsPhosphatidylinositol 3-KinasesShiga ToxinTrihexosylceramidesATPglobotriaosylceramideG proteininositol 1,4,5-triphosphate receptorphosphatidylinositol 4,5-bisphosphateShiga toxin

Identifiers

PMID41809984
PMCPMC12968227

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.