ReviewFrontiers in immunology2025
A critical guideline for controlling monocyte-derived macrophages phenotypes.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Immune dysregulation in osteoarthritis: Mechanisms, biomarkers, and therapeutic opportunities.Journal of translational autoimmunity · 2026Review
- Mechanobiological feedback loops and quantitative decision thresholds in organ fibrosis: Translational principles for antifibrotic therapy.Journal of cell communication and signaling · 2026Review
- Differential Expression and Function of Arginase in Mouse Uterus During Early Pregnancy.International journal of molecular sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Macrophages (Mϕ) are an extremely heterogeneous and rapidly adapting set of innate immune cells that are scattered throughout all tissues in humans from mid-gestation onwards. Their original definition as key players in phagocytosis and defense against pathogens is too restrictive nowadays, as Mϕ are central to tissue homeostasis, repair, and complex immune regulations involving adaptive immunity. The Mϕ exhibit different ontogenies, originating from either embryonic progenitors or bone marrow, and their fate is shaped by tissue-specific microenvironments, which determine their adaptive phenotypes. This results in functional flexibility, exemplified by their ability to polarize into pro- (M1) or anti- (M2) inflammatory states in response to environmental cues. Such a dynamic process is critical for resolving infections, repairing tissue, and maintaining immune balance. Dysregulated Mϕ polarization is indeed implicated in various pathologies, including chronic inflammation, cancer, and fibrosis. Despite their importance, the study of tissue-resident Mϕ is still limited by technical challenges related to their isolation, maintenance, and donor variability. As an alternative, monocyte-derived macrophages (MDMs) represent an easier
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.