Evidence map›Paper›PMID 41810016›Full record

ArticleBioactive materials2026

Near infrared enhanced palladium loaded siraitia grosvenorii carbon dots amplify mitophagy for acute lung injury immunotherapy.

Jing Zhang, Kunpeng Duan, Qianyue Liu, Shurong Chen, Hongshuai Zheng, Yan Liu, Jing Qian, Mingjing Yin, Jing Liu, Jiaxiao Li and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jing ZhangDepartment of Clinical Laboratory, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Kunpeng DuanDepartment of Gynecology, Department of Emergency, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Qianyue LiuDepartment of Clinical Laboratory, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Shurong ChenDepartment of Clinical Laboratory, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Hongshuai ZhengDepartment of Clinical Laboratory, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Yan LiuDepartment of Nutrition, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Jing QianCardiothoracic Surgery Intensive Care Unit, Cardiovascular Injury and Repair Engineering Research Center of Guangxi Department of Education, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Mingjing YinDepartment of Gynecology, Department of Emergency, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Jing LiuDepartment of Clinical Laboratory, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Jiaxiao LiLife Sciences Institute, Guangxi Medical University, Nanning, Guangxi, 530021, China.
Zhijian LiDepartment of Clinical Laboratory, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Min ChenDepartment of Clinical Laboratory, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Ximei HuangDepartment of Clinical Laboratory, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Faquan LinDepartment of Clinical Laboratory, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Ming GaoDepartment of Gynecology, Department of Emergency, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Lin LiaoDepartment of Clinical Laboratory, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitophagy is a self-protection mechanism for cells to eliminate dysfunctional mitochondria, and maintain mitochondrial homeostasis. Thus, precisely inducing mitophagy represents a promising strategy for acute lung injury (ALI) immunotherapy. Here, the mitochondrial targeted palladium loaded siraitia grosvenorii derived carbon dots (CPs@SS31) were engineered designed to integrate PTT, mitophagy induction, and immunoregulation for synergistic enhanced ALI therapy. CPs@SS31 combining with near infrared (NIR) irradiation not only directly scavenged reactive oxygen species to achieve antioxidant and anti-inflammation, but also amplified mitophagy via activating PINK1/Parkin pathway. Furthermore, it specifically targeted mitochondria to increase ATP production and mitochondrial membrane potential, thereby repairing the mitochondrial function of lipopolysaccharide induced cells. Meanwhile, it also demonstrated that CPs@SS31+NIR efficiently induced macrophage M2 polarization, and upregulated CD4

Indexed as

Acute lung injury immunotherapyMitochondrial targetingMitophagy inductionPd loaded carbon dotsROS scavenging

Identifiers

PMID41810016
PMCPMC12969342

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.