ReviewNeuropsychiatric disease and treatment2026
Inflammatory Cytokines as a Shared Pathophysiological Pathway in Depression and Chronic Insomnia: A Narrative Review of Mechanisms and Clinical Implications.
Review in Neuropsychiatric disease and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Beyond Inflammation: Associations of Depression and Anxiety With Fatigue in Rheumatoid Arthritis.Cureus · 2026Article
- Circadian-immune crosstalk in insomnia disorder: mechanisms and therapeutic implications.Frontiers in neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The comorbidity of depression and chronic insomnia is very common in clinical practice, and there is a complex and close relationship between these two diseases, yet its underlying mechanisms remain incompletely understood. In recent years, inflammatory cytokines have been widely studied as important etiological factors for depression comorbid with chronic insomnia. However, whether inflammation is a cause or consequence of this comorbidity remains debated.This review synthesizes emerging evidence to position inflammatory cytokines not merely as correlates, but as central drivers in the pathophysiological nexus of depression and chronic insomnia. It systematically expounds the inflammatory characteristics and clinical significance of patients with depression comorbid with chronic insomnia, with the aim of reviewing the evidence of the association between inflammatory cytokines and depression comorbid with chronic insomnia, and discussing the potential pathophysiological mechanisms that may explain this association, thereby providing a robust scientific foundation for the development of novel ant-inflammatory therapeutic strategies and precision medicine approaches for this challenging comorbidity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.