SynthesisFrontiers in public health2026
Exercise training and balance function in middle-aged and older adults with diabetic peripheral neuropathy: a GRADE-based systematic review and meta-analysis.
Synthesis in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Virtual Reality-Based Rehabilitation to Improve Mobility and Prevent Falls in Older People With Diabetic Peripheral Neuropathy: Evidence Synthesis and Development of a Geriatric-Specific Framework.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2026Pooled it
- Normalized EMG Amplitude During Repeated Sit-to-Stand Transfers in Patients with Diabetic Peripheral Neuropathy.Bioengineering (Basel, Switzerland) · 2026Article
- Exercise and physical activity interventions in type 2 diabetes mellitus.Frontiers in endocrinology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To systematically evaluate, using the GRADE framework, the effects of exercise training on static and dynamic balance function in middle-aged and older adults with DPN. Methods: We systematically searched the Cochrane Library, EMBASE, PubMed, Web of Science, CNKI, and Scopus from inception to March 21, 2025, for randomized controlled trials (RCTs) investigating exercise interventions targeting balance in adults with DPN. Eligible studies enrolled middle-aged and older adults with DPN and reported at least one validated balance-related outcome. Risk of bias was assessed, and the certainty of evidence was rated using the GRADE approach. Meta-analyses were performed using R software and expressed as mean differences (MDs) with 95% confidence intervals (CIs). Results: Sixteen RCTs involving 759 middle-aged and older adults with DPN were included. Low to very low certainty evidence indicated that exercise training significantly improved Berg Balance Scale scores [ Conclusion: Exercise training may confer beneficial effects on both static and dynamic balance function in middle-aged and older adults with DPN, although the certainty of evidence is generally low to very low. No significant effect was found on six-min walking capacity. Larger, pragmatic trials are needed to confirm effects and to guide implementation in community and outpatient services, including monitoring of fall-related and longer-term functional outcomes. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261305039.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.