ArticleFrontiers in neuroscience2025
A novel TGFβ1-Hs3st2-tau axis regulates tau pathology and synaptic integrity.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Lipid metabolic regulation of neuroinflammation in Alzheimer's disease.Frontiers in immunology · 2026Review
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10 authors.
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Abstract
Introduction: Tauopathies are a group of neurodegenerative diseases characterized by the pathological accumulation of tau protein. The hippocampus, a brain region crucial for learning and memory, is particularly susceptible to tau-induced damage. However, the molecular mechanisms underlying this vulnerability remain poorly understood. Here, we identified a novel TGFβ1-HS3ST2-tau signaling axis involved in tau pathology and synaptic impairment. Methods: We used primary hippocampal neurons from a transgenic mouse model of tauopathy to investigate the relevance of TGFβ1 signaling on Results: TGFβ1 signaling enhanced Discussion: These findings define a new TGFβ1-
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