Evidence map›Paper›PMID 41810334›Full record

ArticleResearch and practice in thrombosis and haemostasis2026

Impact of recalcification on procoagulant collagen-and-thrombin-activated (COAT) platelet generation in platelet-rich plasma samples with low platelet counts.

Lydia Hayenga, Lucas Veuthey, Manuel Krüsi, Kamand Haeri, Debora Bertaggia Calderara, Lorenzo Alberio, Alessandro Aliotta

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In one paragraph

Article in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lydia HayengaDivision of Hematology and Central Hematology Laboratory, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Lucas VeutheyDivision of Hematology and Central Hematology Laboratory, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Manuel KrüsiDivision of Hematology and Central Hematology Laboratory, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Kamand HaeriDivision of Hematology and Central Hematology Laboratory, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Debora Bertaggia CalderaraDivision of Hematology and Central Hematology Laboratory, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Lorenzo AlberioDivision of Hematology and Central Hematology Laboratory, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Alessandro AliottaDivision of Hematology and Central Hematology Laboratory, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Assessment of platelet procoagulant function by flow cytometry is increasingly recognized for diagnosing platelet disorders. Induction and accurate detection of phosphatidylserine exposure on the platelet surface requires proper recalcification of citrated blood samples, particularly in plasma from thrombocytopenic patients, in which residual citrate can limit free extracellular calcium availability. Objectives: To define optimal recalcification conditions for reliable measurement of procoagulant Collagen-And-Thrombin-activated (COAT) platelets in platelet-rich plasma (PRP) samples with low platelet counts. Methods: Fresh PRP from healthy donors was diluted with autologous platelet-poor plasma to simulate platelet counts from 160 × 10 Results: For PRP with platelet counts ≥100 × 10 Conclusions: Optimized PRP recalcification prevents underestimation of procoagulant platelet potential in thrombocytopenic samples. This practical approach addresses a key gap identified by the International Society on Thrombosis and Haemostasis Scientific and Standardization Committee and helps laboratories to ensure reliable platelet function testing in PRP samples from thrombocytopenic patients.

Indexed as

annexin Vpre-analyticprocoagulant COAT plateletrecalcificationthrombocytopenia

Identifiers

PMID41810334
PMCPMC12969101

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.