Evidence map›Paper›PMID 41810440›Full record

ArticleWorld journal of gastroenterology2026

Evaluation of a 3,5-diethoxycarbonyl-1,4-dihydrocollidine diet-induced mouse model in a comparative experimental study of portal hypertension.

Jin-Bo Zhao, Zheng-Hao Wu, Jia-Yun Lin, Gu-Qing Luo, Chi-Hao Zhang, Guang-Bo Wu, Qiang Fan, Xiao-Liang Qi, Hai-Zhong Huo, Ji-Wei Yu and 3 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jin-Bo ZhaoDepartment of General Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China.
Zheng-Hao WuDepartment of General Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China.
Jia-Yun LinDepartment of General Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China.
Gu-Qing LuoDepartment of General Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China.
Chi-Hao ZhangDepartment of General Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China.
Guang-Bo WuDepartment of General Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China.
Qiang FanDepartment of General Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China.
Xiao-Liang QiDepartment of General Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China.
Hai-Zhong HuoDepartment of General Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, China.
Ji-Wei YuDepartment of General Surgery, Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 201999, China.
Hong-Jie LiDepartment of General Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China.
Lei ZhengDepartment of General Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China.
Meng LuoDepartment of General Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China. luosh9hospital@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPortal hypertension (PHT) is a life-threatening complication of chronic liver disease, necessitating reliable animal models that mimic its clinical heterogeneity. Classical mouse models like bile duct ligation (BDL) exhibit a low 4-week survival (35%), while carbon tetrachloride (CCl

aimTo evaluate the 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet-induced mouse model as a biliary PHT model, comparing it to BDL and CCl

methodsMice were assigned to DDC diet, BDL, or CCl

resultsAt 4 weeks, DDC induced portal pressure comparable to BDL and CCl

conclusionThe DDC model offers strong biliary PHT relevance, high survival, and efficiency, making it a superior alternative to BDL and CCl

Indexed as

Disease Models, AnimalHypertension, PortalPyridinesAnimalsBile DuctsCarbon TetrachlorideHepatic Stellate CellsLigationLiverMaleMiceMice, Inbred C57BLNitric Oxide Synthase Type IIIPortal Pressure3,5-diethoxycarbonyl-1,4-dihydrocollidineCarbon TetrachlorideNitric Oxide Synthase Type IIIPyridines3,5-diethoxycarbonyl-1,4-dihydrocollidineChronic liver diseaseDuctular reactionMouse modelPortal hypertensionPortal pressure

Identifiers

PMID41810440
PMCPMC12968609

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.