Evidence map›Paper›PMID 41810557›Full record

ArticlePhysiological reports2026

The effect of mitoTEMPO on the development of hypoxia-induced pulmonary hypertension in male mice.

Esraa M Zeidan, Sai Aparna Nagarajan, Akylbek Sydykov, Jens Bier, Monika Brosien, Ashraf Taye, Oleg Pak, Hossein A Ghofrani, Ralph Theo Schermuly, Werner Seeger and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Esraa M ZeidanExcellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, Giessen, Germany.
Sai Aparna NagarajanExcellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, Giessen, Germany.
Akylbek SydykovExcellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, Giessen, Germany.
Jens BierExcellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, Giessen, Germany.
Monika BrosienExcellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, Giessen, Germany.
Ashraf TayeDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, South Valley University, Qena, Egypt.
Oleg PakExcellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, Giessen, Germany.
Hossein A GhofraniExcellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, Giessen, Germany.
Ralph Theo SchermulyExcellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, Giessen, Germany.
Werner SeegerExcellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, Giessen, Germany.
Norbert WeissmannExcellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, Giessen, Germany.
Natascha SommerExcellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, Giessen, Germany.ORCID https://orcid.org/0000-0002-8915-7762
Claudio NardielloExcellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University, Giessen, Germany.ORCID https://orcid.org/0000-0002-4287-6372

Funding

Cardio-Pulmonary Institute (CPI) 390649896Deutsche Forschungsgemeinschaft (DFG) 268555672Deutsche Forschungsgemeinschaft (DFG) and NSF (National Science Foundation) 521904638
6 · The paper itself

Abstract

Mitochondrial reactive oxygen species (mtROS) have been implicated in the development of chronic hypoxia-induced pulmonary hypertension (PH), potentially through hypoxia-inducible factor-1α (HIF-1α) stabilization. However, the role of mtROS in HIF-1α stabilization, PH development, and the therapeutic potential of antioxidant treatment remains controversial. Mice were exposed to hypoxia (10% O

Indexed as

AntioxidantsHypertension, PulmonaryHypoxiaOrganophosphorus CompoundsAnimalsCell ProliferationHumansHypoxia-Inducible Factor 1, alpha SubunitMaleMiceMice, Inbred C57BLMyocytes, Smooth MusclePiperidinesPulmonary ArteryReactive Oxygen SpeciesAntioxidantsHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitMitoTEMPOOrganophosphorus CompoundsPiperidinesReactive Oxygen Specieschronic hypoxiaHIF‐1αmitoTEMPOpulmonary hypertension

Identifiers

PMID41810557
PMCPMC12976977

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.