Disulfidptosis modification patterns are involved in the immune microenvironment regulation of septic acute respiratory distress syndrome.

Disulfidptosis is a new form of programmed cell death. However, there is limited information available regarding the impact of disulfidptosis on septic acute respiratory distress syndrome (ARDS). The 16 disulfidptosis-related genes (DRGs) were collected from a previous study. Gene expression data of sepsis and septic ARDS samples were downloaded from the Gene Expression Omnibus database. The risk score model in septic ARDS was constructed based on the DRGs, followed by the investigation of immune microenvironment in septic ARDS patients. Furthermore, septic ARDS patients were divided into different subtypes based on disulfidptosis modification patterns, and their immune characteristics were investigated. Finally, the differentially expressed genes among different subtypes were identified, and a diagnostic model was constructed. The risk score model based on 6 DRGs was constructed to distinguish sepsis patients from septic ARDS patients, with good performance. The immune microenvironment in septic ARDS patients was slightly different from sepsis patients. Additionally, septic ARDS patients were divided into two subtypes based on DRGs. Finally, three diagnostic models based on 3 hub genes were constructed to classify the two subtypes in septic ARDS patients. Our findings indicated that disulfidptosis might play a role in the immune microenvironment of septic ARDS.